Research Catalog

Title

Microbial genomics and drug discovery / edited by Thomas J. Dougherty, Steven J. Projan.

Publication

New York : Marcel Dekker, c2003.

Items in the Library & Off-site

Details

Additional Authors

• Dougherty, Thomas J. (Thomas John), 1950-
• Projan, Steve

Description

xi, 243 p. : ill.; 24 cm.

Subjects

• Drug development
• Genomics
• Pharmacogenomics
• Antibiotics
• Gene mapping
• Pharmacogenetics
• Microbial genetics
• Genetics, Microbial
• Drug Evaluation > methods
• Drug Resistance, Microbial > genetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Global Aspects of Antibiotic Resistance / Julian Davies -- 2. Genomics of Bacterial Pathogens / Steven R. Gill, Karen E. Nelson and Claire M. Fraser -- 3. Bioinformatics, Genomics, and Antimicrobial Drug Discovery / Brian A. Dougherty and Daniel B. Davison -- 4. The Pathway Tools Software and Its Role in Antimicrobial Drug Discovery / Peter D. Karp -- 5. Genomic Strategies in Antibacterial Drug Discovery / Christopher P. Gray and Wolfgang Keck -- 6. Genomics-Based Approaches to Novel Antimicrobial Target Discovery / Thomas J. Dougherty, John F. Barrett and Michael J. Pucci -- 7. Pathogenesis Genes as Novel Targets / Andrea Marra -- 8. Application of Genomics to the Discovery of New Drugs Against Tuberculosis / Richard A. Slayden, Dean C. Crick, Michael R. McNeil and Patrick J. Brennan -- 9. Phenotype MicroArrays: Their Use in Antibiotic Discovery / Barry R. Bochner -- 10. Microbial Proteomics: New Approaches for Therapeutic Vaccines and Drug Discovery / C. Patrick McAtee -- 11. Surrogate Ligand-Based Assay Systems for Discovery of Antibacterial Agents for Genomic Targets / Dale J. Christensen and Paul T. Hamilton -- 12. Expression Profiling Uses in Antibacterial Chemotherapy Development / Paul M. Dunman and Steven J. Projan -- 13. Using Fungal Genomes for the Discovery, Development, and Clinical Application of Novel and Current Antifungal Therapeutics / Todd A. Black, Joan K. Brieland, Jonathan Greene, Catherine Hardalo, Scott S. Walker and Guillaume Cottarel -- 14. Genomics in Novel Natural Products Generation / Zhiqiang An and William R. Strohl.

ISBN

0824740416 (alk. paper)

LCCN

2004270533

OCLC

• ocm52513079
• SCSB-4883270

Owning Institutions

Columbia University Libraries