Research Catalog

Title

Proteasome inhibitors in cancer therapy / edited by Julian Adams.

Publication

Totowa, N.J. : Humana Press, [2004], ©2004.

Items in the Library & Off-site

Details

Additional Authors

Adams, Julian, 1954-

Description

xiii, 312 pages, 8 unnumbered pages of plates : illustrations (some color); 26 cm.

Series Statement

Cancer drug discovery and development

Uniform Title

Cancer drug discovery and development.

Subjects

• Neoplasms > drug therapy
• Cancer > Chemotherapy
• Drug Evaluation, Preclinical
• Clinical Trials as Topic
• Protease inhibitors > Therapeutic use
• Drug Design
• Protease Inhibitors > therapeutic use

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Cancer drug development : challenges in a competitive market / Barry Greene and Michael Kauffman -- 2. Introduction to the proteasome and its inhibitors : biochemistry and cell biology / Alfred L. Goldberg -- 3. Structures of the yeast proteasome core particle in complex with inhibitors / Michael Groll and Robert Huber -- 4. Natural product and synthetic proteasome inhibitors / Kyung Bo Kim and Craig M. Crews -- 5. Other proteasome inhibitors / Carlos Garcia-Echeverria -- 6. The proteasome in cell-cycle regulation / Julian Adams -- 7. Proteasome inhibition and apoptosis / Simon A. Williams and David J. McConkey -- 8. The proteasome and the COMPARE algorithm / Susan L. Holbeck and Edward A. Sausville -- 9. The proteasome in cancer biology and therapy / Frank Pajonk and William H. McBride -- 10. Radiosensitization and proteasome inhibition / Carter Van Waes, John B. Sunwoo, William DeGraff and James B. Mitchell -- 11. Proteasome-dependent regulation of NF-[kappa]B activation : molecular targeting of chemotherapy resistance / James C. Cusack, Jr. -- 12. Bortezomib with taxanes / Leonard Liebes, Bruce Ng, Yi-He Ling and Roman Perez-Soler -- 13. Proteasome inhibitor therapy in a brain tumor model / Jeffrey J. Olson, Geoffrey Bowers and Zhaobin Zhang -- 14. Anthracyennes and bortezomib / Robert Z. Orlowski -- 15. TNF-related apoptosis-inducing ligand (TRAIL) : combination with proteasome inhibition for anticancer therapy? / Thomas J. Sayers -- 16. Rationale for combining the proteasome inhibitor bortezomib with cisplatin / Edward G. Mimnaugh and Leonard M. Neckers -- 17. The effects of the HIV-1 protease inhibitor ritonavir on proteasome activity and antigen presentation / Marcus Groettrup, Rita de Giuli and Gunter Schmidtke -- 18. Function(s) of the ubiquitin-proteasome system in retrovirus budding / Ulrich Schubert -- 19. Preclinical development of bortezomib (VELCADE) : rationale for clinical studies / Julian Adams, Peter J. Elliott and Page Bouchard -- 20. Phase I trials : bortezomib alone and in combination with standard chemotherapies / Dixie-Lee W. Esseltine and David P. Schenkein -- 21. Clinical molecular diagnostics for proteasome inhibitors in cancer therapy / Jeffrey S. Ross, Gerald P. Linette, Geoffrey S. Ginsburg, William Trepicchio, Oscar Kashala, Rebecca Mosher, Jeffrey Brown, George Mulligan, Jim Deeds and James Stec -- 22. Phase II trials of bortezomib for the treatment of multiple myeloma / Kenneth C. Anderson.

ISBN

• 1588292509 (alk. paper)
• 1592597947 (e-ISBN)

LCCN

2003027863

Owning Institutions

Columbia University Libraries