Research Catalog
DNA methylation : approaches, methods, and applications
- Title
- DNA methylation : approaches, methods, and applications / edited by Manel Esteller.
- Publication
- Boca Raton : CRC Press, [2005], ©2005.
Items in the Library & Off-site
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1 Item
| Status | Format | Access | Call Number | Item Location |
|---|---|---|---|---|
| Text | Request in advance | QP624.5.M46 D626 2005 | Off-site |
Holdings
Details
- Additional Authors
- Esteller, Manel.
- Description
- 223 pages : illustrations (some color); 25 cm
- Summary
- "The book is a state-of-the-art reference for understanding the role DNA methylation plays in human disease, particularly cancer. Written by leaders in the field, this compilation of articles outlines the best techniques to address questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book also provides a balance between articles clarifying methodological details and general review chapters that offer broad biological perspectives on DNA methylation." "Covering fundamental theory, technologies, and applications, DNA Methylation: Approaches, Methods, and Applications presents the most current research on using DNA methylation to decipher the pathways involved in human disease. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing."--BOOK JACKET.
- Subjects
- Genre/Form
- Handbook.
- Bibliography (note)
- Includes bibliographical references and index.
- Contents
- Ch. 1. Impact of DNA methylation on health and disease / Manel Esteller -- Ch. 2. Uses of DNA methylation in cancer diagnosis and risk assessment / Carmen Jeronimo, Rui Henrique and David Sidransky -- Ch. 3. DNA methylation in X inactivation, imprinting, and associated diseases / Maria Rosaria Matarazzo, Maria Strazzullo and Maurizio D'Esposito -- Ch. 4. Studying mammalian DNA methylation : bisulfite modification / Susan J. Clark -- Ch. 5. Bisulfite PCR-based techniques for the study of DNA methylation / James G. Herman -- Ch. 6. Microarray analysis of DNA methylation targets identified by methyl-CpG-binding proteins / Masahiko Shiraishi, Michael W.-Y. Chan and Tim H.-M. Huang -- Ch. 7. Arbitrarily primed-PCR and related DNA methylation methodologies / Jordi Frigola, Maria F. Paz, Manel Esteller and Miguel A. Peinado -- Ch. 8. Discovering DNA methylation differences with restriction landmark genomic scanning / Christoph Plass, Laura J. Rush, Dominic J. Smiraglia and Joseph F. Costello -- Ch. 9. Quantitative determination of 5-methylcytosine DNA content : HPCE and HPLC / Mario F. Fraga and Manel Esteller -- Ch. 10. Qualitative determination of 5-methylcytosine and other components of the DNA methylation machinery : immunofluorescence and chromatin immunoprecipitation / Jesus Espada, Esteban Ballestar and Manel Esteller -- Ch. 11. Mouse models for the study of DNA methylation / Nicole M. Sodir and Peter W. Laird -- Ch. 12. DNA demethylating agents : concepts / Jonathan C. Cheng, Daniel J. Weisenberger and Peter A. Jones -- Ch. 13. DNA demethylating agents : preclinical evaluation as anticancer agents / Robert Brown -- Ch. 14. DNA demethylating agents : clinical uses / Michael Lubbert, Jens Hasskarl and Rainer Claus.
- ISBN
- 084932050X (alk. paper)
- LCCN
- 2004049665
- OCLC
- ocm55000608
- SCSB-5081592
- Owning Institutions
- Columbia University Libraries