Research Catalog

Title

Chemogenomics in drug discovery : a medicinal chemistry perspective / edited by Hugo Kubinyi and Gerhard Müller.

Publication

Weinheim : Wiley-VCH, [2004], ©2004.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Kubinyi, Hugo.
• Müller, Gerhard, 1963-

Description

xxiv, 463 pages : illustrations (some color), portrait; 25 cm.

Series Statement

Methods and principles in medicinal chemistry ; v. 22

Uniform Title

Methods and principles in medicinal chemistry ; v. 22.

Subject

• Pharmacogenetics
• Combinatorial Chemistry Techniques
• Drug Design
• Genomics
• Drug development
• Pharmaceutical chemistry

Bibliography (note)

• Includes bibliographical references and index.

Contents

Target family-directed masterkeyes in chemogenomics / Gehard Müller -- Drug discovery from side effects / Hugo Kubinyi -- The value of chemical genetics in drug discovery / Keith Russell and William F. Michne -- Structural aspects of binding site similarity: a 3D upgrade for chemogenomics / Andreas Bergner and Judith Günther -- The contribution of molecular informatics to chemogenomics: knowledge-based discovery of biological targets and chemical lead compounds / Edgar Jacoby, Ansgar Schuffenhauer, and Pierre Acklin -- Chemical kinomics / Bert M. Klebl, Henrik Daub, and György Kéri -- Structural aspects of kinases and their inhibitors / Rogier Buijsman -- A chemical genomics approach for ion channel modulators / Karl-Heinz Baringhaus and Gerhard Hessler -- Phosphodiesterase inhibitors: a chemogenomic view / Martin Hendrix and Christopher Kallus -- Proteochemometrics: a tool for modeling the molecular interaction space / Jarl E.S. Wikberg, Maris Lapinsch, and Peteris Prusis -- Some principles related to chemogenomics in compound library and template design for GPCRs / Thomas R. Webb -- Computational filters in lead generation: targeting drug-like chemotypes / Wolfgang Guba and Olivier Roche -- Navigation in chemical space: ligand-based design of focused compound libraries / Gisbert Schneider and Petra Schneider -- Natural product-derived compound libraries and protein structure similarity as guiding principles for the discovery of drug candidates / Marcus A. Koch and Herbert Waldmann -- Combinatorial chemistry in the age of chemical genomics / Reni Joseph and Prabhat Arya.

ISBN

352730987X (hbk. : alk. paper)

OCLC

• ocm56515194
• SCSB-5135482

Owning Institutions

Columbia University Libraries