Research Catalog

Title

Biomaterials for delivery and targeting of proteins and nucleic acids / edited by Ram I. Mahato.

Publication

Boca Raton : CRC Press, [2005], ©2005.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Mahato, Ram I.

Description

xxxii, 669 pages : illustrations; 24 cm

Summary

"Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry and covers the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles." "No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present detailed information on biological barriers to extravasation and cellular uptake of proteins and nucleic acids."--BOOK JACKET.

Subject

• Polymeric drug delivery systems
• Peptide drugs > Dosage forms
• Nucleic acids > Therapeutic use
• Polymers > therapeutic use
• Biocompatible Materials > therapeutic use
• Drug Delivery Systems
• Peptide Nucleic Acids > therapeutic use

Bibliography (note)

• Includes bibliographical references and index.

Contents

Ch. 1. Structure, properties, and characterization of polymeric biomaterials / Anjan Nan and Hamidreza Ghandehari -- Ch. 2. Step-growth and ring-opening polymerization / Rajendra P. Pawar and Abraham J. Domb -- Ch. 3. Copolymers, block copolymers, and stimuli-sensitive polymers / Kang Moo Huh, Sang Cheon Lee, Young Jin Kim and Kinam Park -- Ch. 4. Polymer solution properties, micelles, dendrimers, and hydrogels / Tooru Ooya and Kinam Park -- Ch. 5. Protein conjugation, cross-linking, and PEGylation / Kenneth D. Hinds -- Ch. 6. Complement activation by injectable colloidal drug carriers / Catherine Passirani and Jean-Pierre Benoit -- Ch. 7. Biological membranes and barriers / Yadollah Omidi and Mark Gumbleton -- Ch. 8. Pharmacokinetics of protein- and nucleotide-based drugs / Bernd Meibohm -- Ch. 9. In vivo fate of polymeric gene carriers / Dagmar Fischer -- Ch. 10. Subcellular fate of proteins and nucleic acids / David Oupicky -- Ch. 11. Stability of proteins and nucleic acids / Zheng-Rong Lu -- Ch. 12. Formulation, stability, and characterization of protein and peptide drugs / Sven Frokjaer, Lars Hovgaard and Marco van de Weert -- Ch. 13. Micro- and nanoparticulate polymeric delivery systems for nucleic acid-based medicine / Shikha P. Barman and Mary Lynne Hedley -- Ch. 14. Liposomal delivery of protein and peptide drugs / Vladimir P. Torchilin -- Ch. 15. Mechanisms of cellular drug resistance and strategies to overcome it / Tamara Minko -- Ch. 16. Transporters as molecular targets for drug delivery and disposition / Ikumi Tamai -- Ch. 17. Protein transduction domain as a novel tool for delivery of proteins, peptides and nucleic acids / Ricardo L. Pastori, Melina M. Ribeiro, Dagmar Klein and Camillo Ricordi -- Ch. 18. Introduction to therapeutic nucleic acids / Andreas G. Schatzlein -- Ch. 19. Antisense and antigene oligonucleotides : structure, stability and delivery / Ram I. Mahato, Zhaoyang Ye and Ramareddy V. Guntaka -- Ch. 20. Artificial nucleic acid chaperones / Atsushi Maruyama -- Ch. 21. Basic components of plasmid-based gene expression systems / Minhyung Lee and Sung Wan Kim -- Ch. 22. Design elements of polymeric gene carriers / Joon Sig Choi and Jong-Sang Park.

ISBN

0849323347 (alk. paper)

LCCN

2004055434

OCLC

• ocm56807542
• SCSB-5165777

Owning Institutions

Columbia University Libraries