Research Catalog
Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists
- Title
- Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists / Robert A. Copeland.
- Author
- Copeland, Robert Allen.
- Publication
- Hoboken, N.J. : J. Wiley, 2005.
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| Status | Format | Access | Call Number | Item Location |
|---|---|---|---|---|
| Text | Request in advance | QD271 .M46 v.46 | Off-site | |
Not available - Please for assistance. | Text | Use in library | Off-site |
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Details
- Description
- xvii, 271 pages : illustrations; 25 cm
- Summary
- "This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications."--BOOK JACKET.
- Subjects
- Bibliography (note)
- Includes bibliographical references and index.
- Contents
- 1. Why enzymes as drug targets? -- 2. Enzyme reaction mechanisms -- 3. Reversible modes of inhibitor interactions with enzymes -- 4. Assay considerations for compound library screening -- 5. Lead optimization and structure-activity relationships for reversible inhibitors -- 6. Slow binding inhibitors -- 7. Tight binding inhibitors -- 8. Irreversible enzyme inactivators -- App. 1. Kinetics of biochemical reactions -- App. 2. Derivation of the enzyme-ligand binding isotherm equation -- App. 3. Serial dilution schemes.
- ISBN
- 0471686964 (cloth : alk. paper)
- LCCN
- 2004023470
- OCLC
- 56793559
- ocm56793559
- SCSB-5166298
- Owning Institutions
- Columbia University Libraries