Research Catalog

Title

Toxicology of the kidney / edited by Joan B. Tarloff and Lawrence H. Lash.

Publication

Boca Raton : CRC Press, [2005], ©2005.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Tarloff, Joan B.
• Lash, Lawrence H.

Description

xxi, 1176 pages : illustrations; 25 cm.

Summary

"Updated to reflect the latest research in this field, Toxicology of the Kidney, Third Edition explores the correlation between anatomy, biochemistry, and physiology of the kidney. The text explains how these factors are related to concepts of clinical nephrotoxicity and renal failure in humans, and how animal models can be used to understand the mechanisms of human renal disease." "In addition to updating many of the key elements of previous editions, the book incorporates cutting-edge information on newly emerging areas of renal research. Filled with current reviews of unpublished and recently published information, the book is a concise compendium of many key topics that will continue to play a central role in understanding and treating nephrotoxicity for decades to come."--BOOK JACKET.

Series Statement

Target organ toxicology series

Uniform Title

Target organ toxicology series.

Subjects

• Kidney > drug effects
• Nephrotoxicology
• Kidney Function Tests
• Kidney Diseases > chemically induced

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Anatomy and physiology of the kidneys -- 2. Molecular and cell biology of normal and diseased or intoxicated kidney -- 3. Assessing renal effects of toxicants in vivo -- 4. In vitro techniques in screening and mechanistic studies : organ perfusion, slices and nephron components -- 5. In vitro techniques in screening and mechanistic studies : cell culture, cell-free systems, and molecular and cell biology -- 6. Role of xenobiotic metabolism -- 7. Mechanisms of renal cell death -- 8. Signal transduction in renal cell repair and regeneration -- 9. Chemical-induced nephrocarcinogenicity in the Eker rat : a model of chemical-induced renal carcinogenesis -- 10. The role of endocytosis in nephrotoxicity -- 11. Role of cellular energetics in nephrotoxicity -- 12. Adhesion molecules in renal physiology and pathology -- 13. Oxidant mechanisms in toxic acute renal failure -- 14. Vasoactive and inflammatory substances -- 15. Analgesic nephropathy -- 16. Antibiotic-induced nephrotoxicity -- 17. Nephrotoxicity of cyclosporine and other immunosuppressive and immunotherapeutic agents -- 18. Cisplatin-induced nephrotoxicity -- 19. The pathogenesis and prevention of radiocontrast medium induced renal dysfunction -- 20. Analgesics and non-steroidal anti-inflammatory drugs -- 21. Mycotoxins affecting the kidney -- 22. Nephrotoxicology of metals -- 23. Chemical-induced nephrotoxicity mediated by glutathione s-conjugate formation -- 24. The role of epidemiology in human nephrotoxicity -- 25. Age, sex and species differences in nephrotoxic response -- 26. Risk assessment of nephrotoxic metals -- 27. Risk assessment for selected therapeutics.

ISBN

0415248647

OCLC

• 59879763
• ocm59879763
• SCSB-5166867

Owning Institutions

Columbia University Libraries