Research Catalog

Title

Translational and experimental clinical research / [edited by] Daniel P. Schuster, William J. Powers.

Publication

Philadelphia : Lippincott Williams & Wilkins, c2005.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Schuster, Daniel P.
• Powers, William J., MD.

Description

xxi, 490 p., [4] p. of plates : ill. (some col.); 26 cm.

Summary

"An explosion of new basic knowledge has created enormous opportunities to improve human health. Before such information can be converted into effective changes in daily medical practice, its relevance to human disease must be understood first. With this comprehensive text, you'll explore detailed guidelines for designing and conducting clinical research studies, advice on analyzing and reporting results, discussions of key ethical and regulatory issues, and the application of the tools of modern biology to human investigation."--BOOK JACKET.

Subject

• Medicine > Methodology
• Medicine > Statistical methods
• Clinical trials > Methodology
• Biomedical Research > methods
• Clinical Trials > methods
• Research Design
• Data Interpretation, Statistical

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Defining the research question -- 2. Searching the literature -- 3. Variables and measurements -- 4. Study eligibility and participant selection -- 5. Recruiting research participants -- 6. Reducing bias -- 7. Observational study designs -- 8. Experimental study designs -- 9. Estimating sample size -- 10. Database development -- 11. Case report form development -- 12. Data collection and quality control -- 13. Monitoring experimental interventions -- 14. Responsible conduct of research -- 15. Regulatory oversight -- 16. Funding clinical research -- 17. Research budgeting -- 18. "Small" clinical experiments -- 19. Clinical studies in pediatric minority populations -- 20. Pharmacokinetics and pharmacodynamics -- 21. Gene therapy and pharmacogenomic studies -- 22. Preparing for gene therapy studies -- 23. Overview : hypothesis testing and summary statistics -- 24. Group comparisons -- 25. Regression -- 26. Multivariate analysis -- 27. Biostatistical consulting -- 28. Statistical computing -- 29. Presenting data in manuscripts -- 30. Visual presentation of data -- 31. Fundamentals of gene expression -- 32. Identifying mutations and polymorphisms -- 33. Cloning methods -- 34. Transcriptional profiling -- 35. Proteomics -- 36. Cell and tissue imaging techniques -- 37. Non-imaging cell and tissue techniques and tissue banking -- 38. Evaluating substrate metabolism -- 39. Medical images as scientific data.

ISBN

0781755654 (alk. paper)

LCCN

2005011068

OCLC

ocm58828632

Owning Institutions

Columbia University Libraries