Research Catalog

Title

Biomarkers in breast cancer : molecular diagnostics for predicting and monitoring therapeutic effect / edited by Giampietro Gasparini and Daniel F. Hayes.

Publication

Totowa, N.J. : Humana Press, [2006], ©2006.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Gasparini, Giampietro.
• Hayes, Daniel, 1951-

Description

xi, 341 pages : illustrations; 24 cm.

Summary

"It is now well recognized that individualized cancer treatment planning, based on tumor characteristics specific to an individual's cancer, makes it easier to select those most likely to benefit from toxic cancer therapies and to avoid treating those least likely to benefit. In Biomarkers in Breast Cancer: Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect, expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers, as well as examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines to the validation of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-I; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers." "Authoritative and cutting-edge, Biomarkers in Breast Cancer: Molecular Diagnostics for Predicting and Monitoring Therapeutic Effect offers laboratory investigators developing new tumor markers, clinical investigators testing them, and clinicians using them as an up-to-date understanding of both the prognostic/predictive indicators and the novel molecular-targeted therapies suitable for individualizing breast cancer therapy."--BOOK JACKET.

Series Statement

Cancer drug discovery and development

Uniform Title

Cancer drug discovery and development.

Subject

• Breast > Molecular diagnosis
• Breast > Prognosis
• Tumor markers
• Breast Neoplasms > diagnosis
• Molecular Diagnostic Techniques
• Biomarkers, Tumor

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Guidelines for the design of clinical studies for the development and validation of therapeutically relevant biomarkers and biomarker-based classification systems / Richard M. Simon -- 2. Analytical aspects of biomarker immunoassays in cancer research / Fred C. G. J. Sweep, Chris M. G. Thomas and Manfred Schmitt -- 3. Tissue microarrays : state of the art, pitfalls, and promises / Chungyeul Kim and Soonmyung Paik -- 4. Gene expression profiling with DNA microarrays : revolutionary tools to help diagnosis, prognosis, treatment guidance, and drug discovery / Michele De Bortoli and Nicoletta Biglia -- 5. Assays for gene amplification : state of the art, pitfalls, and promises / Chungyeul Kim, Yongkuk Song and Soonmyung Paik -- 6. Cell kinetics / Maria Grazia Daidone, Rosella Silvestrini and Dino Amadori -- 7. Urokinase-type plasminogen activator and PAI-1 : validated prognostic factors for breast cancer / Michael J. Duffy -- 8. Predictive value of c-erb-B2 for endocrine therapy and chemotherapy in breast cancer / Vered Stearns -- 9. erb-B2 as a therapeutic target / Robert Mass -- 10. The epidermal growth factor receptor pathway as a selective molecular-targeted treatment in human breast cancer / Fortunato Ciardiello, Teresa Troiani and Giampaolo Tortora -- 11. p53 as a prognostic and predictive indicator / Daniela Kandioler and Raimund Jakesz -- 12. Occult metastatic cells in breast cancer patients : state of the art, pitfalls, and promises / Stephan Braun, Julia Seeber and Christian Marth -- 13. Circulating HER2/neu : clinical utility / Allan Lipton, Laurence Demers, Kim Leitzel, Suhail M. Ali, Rainer Neumann, Christopher P. Price and Walter P. Carney -- 14. Circulating vascular endothelial growth factor : methods, prognostic significance, and potential application for antiangiogenic therapy / Roberta Sarmiento, Roberta Franceschini, Sabrina Meo, Massimo Gion, Raffele Longo and Giampietro Gasparini -- 15. Detection of early tumor dissemination in patients with breast cancer / Debra Hawes and Richard J. Cote -- 16. New technologies/new markers/new challenges / Daniel F. Hayes and Giampietro Gasparini.

ISBN

1588292274 (alk. paper)

LCCN

2005001922

OCLC

• ocm57506505
• SCSB-5220618

Owning Institutions

Columbia University Libraries