Research Catalog

Title

Statistical monitoring of clinical trials : fundamentals for investigators / Lemuel A. Moyé.

Author

Moyé, Lemuel A.

Publication

New York ; London : Springer, 2006.

Items in the Library & Off-site

Holdings

Details

Description

xxi, 254 pages : illustrations; 24 cm

Summary

"Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. Clearly presenting the necessary background with limited use of mathematics, this book increases the knowledge, experience, and intuition of investigations in the use of these important procedures now required by the many clinical research effects." "The author provides motivated clinical investigators the background, correct use, and interpretation of these monitoring procedures at an elementary statistical level. He defines terms commonly used such as group sequential procedures and stochastic curtailment in non-mathematical language and discusses the commonly used procedures of Pocock, O'Brien-Fleming, and Lan-DeMets. He discuses the notions of conditional power, monitoring for safety and futility, and monitoring multiple endpoints in the study. The use of monitoring clinical trials is introduced in the context of the evolution of clinical research, and one chapter is devoted to the more recent Bayesian procedures."--BOOK JACKET.

Subjects

• Clinical Trials as Topic > statistics & numerical data
• Clinical trials > Statistical methods
• Data Interpretation, Statistical

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Here, there be dragons -- 2. The basis of statistical reasoning in medicine -- 3. Probability tools for monitoring rules -- 4. Issues and intuitions in path analysis -- 5. Group sequential analysis procedures -- 6. Looking forward : conditional power -- 7. Safety and futility -- 8. Bayesian statistical monitoring -- App. A. Boundary values for normal mean -- App. B. Conditional Brownian motion -- App. C. Boundary values and conditional power -- App. D. Supporting Bayesian computations -- App. E. Standard normal probabilities.

ISBN

0387277811 (pbk.)

OCLC

• ocm61477759
• SCSB-5221590

Owning Institutions

Columbia University Libraries