Research Catalog

Title

Integrated strategies for drug discovery using mass spectrometry / [edited by] Mike S. Lee.

Publication

Hoboken, N.J. : Wiley-Interscience, [2005], ©2005.

Supplementary Content

• Contributor biographical information
• Publisher description

Items in the Library & Off-site

Holdings

Details

Additional Authors

Lee, Mike S., 1960-

Description

xvii, 550 pages : illustrations; 24 cm

Subjects

• Drug Design
• Massaspectrometrie
• Mass Spectrometry > methods
• Chromatography, Liquid > methods
• Drugs > Analysis
• Pharmaceutical Preparations > analysis
• Geneesmiddelen
• High throughput screening (Drug development)
• Mass spectrometry
• Pharmacokinetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic and Neil L. Kelleher -- 2. Mass-spectrometry-based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- 3. ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery, Lendell L. Cummins, Shuo Chen, Jared J. Drader and Steven A. Hofstadler -- 4. Mass spectrometry-based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads, Haleem J. Isaaq, Josip S. Blonder and Timothy D. Veenstra -- 5. Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor and Elaine Holmes -- 6. The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert, Paul Lewer, Dennis O. Duebelbeis and Andrew W. Carr -- 7. Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng and Jill Hochlowski -- 8. A combinatorial process for drug discovery / David S. Wagner, Richard W. Wagner, Frank Schoenen and H. Mario Geysen -- 9. Application of technological advances in biotransformation studies / Carmen L. Fernandez-Metzler, Raju Subramanian and Richard C. King -- 10. Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang, Jack Wang, Margaret Davis, William DeMaio, JoAnn Scatina and Rasmy Talaat -- 11. Advances in high throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy -- 12. New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- 13. An integrated LC-MS strategy for preclinical candidate optimization / Jonathan L. Josephs and Mark Sanders -- 14. New approaches for method development and purification in lead optimization / Yining Zhao and David J. Semin -- 15. High throughput metabolic and physicochemical property analysis : strategies and tactics for impact on drug discovery success / Edward H. Kerns and Li Di -- 16. Organ perfusion and mass spectrometry / C. Gerald Curtis, Ben Chien, David Bar-Or and Kumar Ramu -- 17. Sample preparation for drug discovery bioanalysis / David A. Wells -- 18. Automation / John D. Laycock and Thomas Hartmann.

ISBN

047146127X (cloth)

LCCN

• 2005003235
• 9780471461272

OCLC

• ocm57579301
• SCSB-5240496

Owning Institutions

Columbia University Libraries