Research Catalog

Title

Integrated drug discovery technologies / edited by Houng-Yau Mei, Anthony W. Czarnik.

Publication

New York : Marcel Dekker, [2002], ©2002.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Mei, Houng-Yau, 1960-
• Czarnik, Anthony W., 1957-

Description

xii, 577 pages : illustrations (some color); 24 cm

Subjects

• Combinatorial Chemistry Techniques
• Chimie combinatoire
• Chemistry, Pharmaceutical
• Drug Design
• High throughput screening (Drug development)
• Médicaments > Développement
• Química médica y farmacéutica
• Drogas
• Drug development
• Criblage à haut débit (Développement des médicaments)
• Farmacología
• Drug Evaluation, Preclinical
• Combinatorial chemistry

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. The Motivation: A Top-Down View / Wendell Wierenga -- 2. Target Identification and Validation: Coupling Genotype to Phenotype / Gary McMaster -- 3. Functional Genomics / David O'Hagan -- 4. Integrated Proteomics Technologies / Joseph A. Loo, James A. Blackledge and Ping Du / [et al.] -- 5. Where Science Meets Silicon: Microfabrication Techniques and Their Scientific Applications / Tony J. Beugelsdijk -- 6. SNP Scoring for Drug Discovery Applications / John P. Nolan, P. Scott White and Hong Cai -- 7. Protein Display Chips / Tina S. Morris -- 8. Integrated Proteomics Technologies and In Vivo Validation of Molecular Targets / Christian Rohlff -- 9. High-Throughput Screening as a Discovery Resource / John P. Devlin -- 10. Fluorescence Correlation Spectroscopy (FCS) and FCS-Related Confocal Fluorimetric Methods (FCS[superscript +] plus): Multiple Read-Out Options for Miniaturized Screening / Cornelia Rufenach, Andreas Scheel and Sylvia Sterrer / [et al.] -- 11. Homogeneous Time-Resolved Fluorescence / Loraine V. Upham, Jocelyn W. Burke and Betty Howard / [et al.] -- 12. ADME-Tox Screening in Drug Discovery / Albert P. Li -- 13. Screening Lead Compounds in the Postgenomic Era: An Integrated Approach to Knowledge Building from Living Cells / Kenneth A. Giuliano, Ravi Kapur and Keith R. Olson / [et al.] -- 14. Miniaturization Technologies for High-Throughput Biology / Walter D. Niles and Peter J. Coassin -- 15. Data Management for High-Throughput Screening / Lee Amon -- 16. Combinatorial Chemistry: The History and the Basics / Michal Lebl -- 17. New Synthetic Methodologies / Tasir S. Haque, Andrew P. Combs and Lorin A. Thompson -- 18. Supports for Solid-Phase Synthesis / Christophe Fromont, Vincent Pomel and Mark Bradley -- 19. The NMR "Toolkit" for Compound Characterization / Paul A. Keifer -- 20. Materials Management / David A. Kniaz.

ISBN

0824706498 (hbk.; alk. paper)

LCCN

2002019330

OCLC

• ocm48958269
• SCSB-5243639

Owning Institutions

Columbia University Libraries