Research Catalog

Title

Histone deacetylases : transcriptional regulation and other cellular functions / edited by Eric Verdin.

Publication

Totowa, N.J. : Humana Press, [2006], ©2006.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Verdin, Eric.

Description

xi, 340 pages : illustrations (some color); 24 cm.

Summary

"In Histone Deacetylases: Transcriptional Regulation and Other Cellular Functions, a panel of investigators summarizes and synthesizes the new discoveries in this rapidly evolving field. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes - both alone and in complex with small-molecule inhibitors - and the biological roles of the several histone deacetylase (HDAC) genes that have been knocked out in mice. This book constitutes a first landmark of what had been accomplished so far and sets a clear agenda for the full definition of HDAC roles in biology and disease in the years to come."--BOOK JACKET.

Series Statement

Cancer drug discovery and development

Uniform Title

Cancer drug discovery and development.

Subject

• Histone deacetylase
• Cell cycle
• Enzymes
• Cancer > Chemotherapy
• Histone Deacetylases > physiology
• Cell Cycle > drug effects
• Enzyme Repression > physiology
• Histone Deacetylase Inhibitors
• Neoplasms > drug therapy
• Sirtuins > physiology

Bibliography (note)

• Includes bibliographical references and index.

Contents

I. Class I histone deacetylases -- 1. Histone deacetylase 1 / Dominique Meunier and Christian Seiser -- 2. Biochemistry of multiprotein HDAC complexes / Alejandro Vaquero, Michael Scher and Danny Reinberg -- 3. The biology of HDAC3 / Edward Seto -- 4. The biology of HDAC8, a unique class I histone deacetylase / David Waltregny and Vincent Castronovo -- II. Class II histone deacetylases -- 5. Regulation of muscle gene expression by histone deacetylases / Timothy A. McKinsey and Eric N. Olson -- 6. The class IIa histone deacetylases : functions and regulation / Herbert G. Kasler and Eric Verdin -- 7. Histone deacetylases in the response to misfolded proteins / J. Andrew McKee and Tso-Pang Yao -- III. Class III histone deacetylases -- 8. Evolution of sirtuins from archaea to vertebrates / Roy A. Frye -- 9. Structure of the Sir2 family of NAD[superscript +]-dependent histone/protein deacetylases / Kehao Zhao and Ronen Marmostein -- 10. The enzymology of SIR2 proteins / Margie T. Borra and John M. Denu -- 11. The class III protein deacetylases : homologs of yeast Sir2p / Bjoern Schwer, Brian J. North, Nidhi Ahuja, Brett Marshall and Eric Verdin -- 12. HDAC inhibitors : discovery, development, and clinical impacts / Akihiro Ito, Norikazu Nishino and Minoru Yoshida -- 13. Cell cycle targets of histone deacetylase inhibitors / Brian Gabrielli -- 14. HDAC inhibitors : an emerging anticancer therapeutic strategy / Paul Kwon, Meier Hsu, Dalia Cohen and Peter Atadja.

ISBN

• 1588294994 (alk. paper)
• 1597450243 (e-ISBN)

LCCN

2005031537

OCLC

• ocm62216887
• SCSB-5250115

Owning Institutions

Columbia University Libraries