Research Catalog

Title

Pathogenesis of human pulmonary tuberculosis : insights from the rabbit model / Arthur M. Dannenberg.

Author

Dannenberg, Arthur M.

Publication

Washington, D.C. : ASM Press, [2006], ©2006.

Items in the Library & Off-site

Holdings

Details

Additional Authors

American Society for Microbiology.

Description

xiv, 453 pages : illustrations; 27 cm

Summary

"This work examines the pathogenesis of human pulmonary tuberculosis in all of its stages, with a primary focus on the experimental rabbit model. Tuberculosis in the rabbit model most closely resembles that found in humans, including caseous necrosis, liquefaction, and cavity formation with bronchial spread of the disease. Other animal models-mouse, guinea pig, and monkey-are compared with the rabbit and human models." "Authored by an experienced and noted expert in the field, Pathogenesis of Human Pulmonary Tuberculosis reviews the interplay of delayed-type hypersensitivity and cell-mediated immunity, clearly showing how both are needed to control the growth of the tubercle bacillus and how antibodies contribute to these cellular immune responses. The pathology and structure of tuberculous lesions are thoroughly investigated. Other significant topics discussed include the histochemistry of macrophage activation; the roles of various cytokines; the effects of glucocorticoids, estrogens, thyroid hormones, and irradiation on the disease; and principles of immunization against tuberculosis, including vaccine development. The final chapter describes many areas in which future research could contribute to our knowledge, treatment, and control of this disease. The text is complemented by high-quality illustrations of both human and rabbit disease. Pathogenesis of Human Pulmonary Tuberculosis updates and revises the ground-breaking work of Max B. Lurie, summarizing the combined 80 years of research by Drs. Lurie and Dannenberg. The book offers a comprehensive resource for clinicians, public health investigators, and laboratory researchers in tuberculosis and immunology. Book jacket."--BOOK JACKET.

Subject

• Lurie, Max B. 1893-1966
• Tuberculosis > Animal models
• Tuberculosis > Pathophysiology
• Tuberculosis, Pulmonary > physiopathology
• Models, Animal
• Mycobacterium bovis > pathogenicity
• Rabbits
• Tuberculosis, Pulmonary > microbiology

Bibliography (note)

• Includes bibliographical references and index.

Contents

Introduction / Max B. Lurie and Arthur M. Dannenberg, Jr. -- Section 1. Pathogenesis of Tuberculosis -- 1. Overview: Childhood and adult tuberculosis, bacillary virulence, host resistance, contagion, and prevention -- 2. Stages in the Pathogenesis of Human and Rabbit Tuberculosis -- 3. Types of Human Pulmonary Tuberculosis -- 4. Liquefaction of Caseous Foci and Cavity Formation -- Section 2. Immunology of Tuberculosis -- 5. Delayed-Type Hypersensitivity, Cell-Mediated Immunity, and Antibodies in Tuberculosis: Their local and systemic natures; innate immunity -- 6. Macrophages and Other Cells in Tuberculous Lesions: Including dendritic cells and lymphocytes -- Section 3. Tuberculous Lesions -- 7. Structural Components of Tuberculous Lesions -- 8. Microvascular Density in Tuberculous Lesions: In developing and healing BCG lesions and in tuberculin reactions -- 9. Early Pulmonary Lesions in Rabbits: Produced by an intravenous injection of tubercle bacilli -- 10. Macrophage Turnover, Division, and Activation in Tuberculous Lesions: In developing, peak, and "healed" BCG lesions -- 11. Lurie's Pulmonary Tubercle-Count Method: To assess bacillary virulence, genetic resistance of the host, and vaccine efficacy -- Section 4. Tuberculosis in Rabbits and other Common Laboratory Animals -- 12. Natural Airborne Infection: Resistance to the establishment of tuberculosis and to its progress -- 13. Response of Rabbits to Inhaled Tubercle Bacilli Including BCG: Response to inhaled bovine- and human-type tubercle bacilli and to inhaled BCG -- 14. Characteristics of Resistance and Susceptibility to Tuberculosis in Lurie's Inbred Rabbits -- 15. Comparisons of Tuberculosis in Rabbits, Mice, and Guinea Pigs -- Section 5. Effects of Hormones and X-Irradiation on Tuberculosis -- 16. Effects of Cortisone and Adrenocorticotropic Hormone on Tuberculosis -- 17. Effects of Estrogen, Chorionic Gonadotropin, and Thyroid Hormones on Tuberculosis -- 18. Effects of Whole-Body X-Irradiation on Tuberculosis -- Section 6. Cytokines and Vascular Adhesion Molecules in Tuberculous Lesions -- 19. Cytokine Production in Primary BCG Lesions: Nonspecific and antigen-specific cytokine production in developing and healing primary BCG lesions -- 20. Cytokine Production in Reinfection BCG Lesions and in Tuberculin Reactions: Effects of immunization on cell composition and cytokines -- 21. Vascular Adhesion Molecules in Tuberculous Lesions: ICAM-1, VCAM-1, and ELAM-1 in developing and healing rabbit dermal BCG lesions -- Section 7. Tuberculosis Vaccines -- 22. Principles and Guidelines for Developing Better Tuberculosis Vaccines -- 23. Characteristics of Rabbit BCG Lesions and Efficacies of BCG and Mycobacterium microti Vaccines -- Section 8. Past, Present, and Future -- 24. Summary and Conclusions -- 25. Suggested Future Research and Unanswered Questions: Research on the host; research on the bacillus; vaccines and immunotherapy; development of new drugs -- A. Award of the Trudeau Medal for 1955: The Trudeau Medal of the National Tuberculosis Association for 1955 awarded to Max B. Lurie -- B. Obituary of Max B. Lurie, M.D. (1893-1966) / Esmond R. Long, M.D., Ph.D., Sc.D. -- C. Publications of Max B. Lurie -- D. Publications of Arthur M. Dannenberg, Jr. -- E. Guidelines for Preventing the Transmission of Mycobacterium tuberculosis in Health-Care Settings, 2005 (Table of Contents): Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, Georgia -- F. Collected Abstracts of Chapters in This Volume -- G. Acknowledgments.

ISBN

• 1555813739
• 9781555813734

LCCN

• 2006021123
• 9781555813734

OCLC

• ocm70218048
• SCSB-5303415

Owning Institutions

Columbia University Libraries