Research Catalog

Title

Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition / editors, Robert A. Bonomo, Marcelo Tolmasky.

Publication

Washington, D.C. : ASM Press, [2007], ©2007.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Bonomo, Robert A.
• Tolmasky, Marcelo.

Description

xviii, 357 pages, 8 unnumbered pages of plates : illustrations (some color); 29 cm

Subject

• Drug resistance in microorganisms
• Drug resistance in microorganisms > Genetic aspects
• Microbial enzymes
• Anti-Bacterial Agents
• Drug Resistance, Bacterial
• Enzyme Inhibitors
• beta-Lactamase Inhibitors

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Overview of aminoglycosides and enzyme-mediated bacterial resistance : clinical implications / Robert A. Bonomo -- 2. Aminoglycoside antibiotics / Kanchana Majumder, Lianhu Wei, Subhash C. Annedi and Lakshmi P. Kotra -- 3. Structural aspects of aminoglycoside-modifying enzymes / Gerard D. Wright and Albert M. Berghuis -- 4. Aminoglycoside-modifying enzymes : characteristics, localization, and dissemination / Marcelo E. Tolmasky -- 5. rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics / Marilyn C. Roberts -- 6. [beta]-lactamases : historical perspectives / Karen Bush and Patricia A. Bradford -- 7. Resistance mediated by penicillin-binding proteins / Malcolm G. P. Page -- 8. Inhibition of class A [beta]-lactamases / Samy O. Meroueh, Jooyoung Cha and Shahriar Mobashery -- 9. Class B [beta]-lactamases / Gian Maria Rossolini and Jean-Denis Docquier -- 10. Crystal structures of class C [beta]-lactamases : mechanistic implications and perspectives in drug design / C. Bauvois and J. Wouters -- 11. Class D [beta]-lactamases / Franck Danel, Malcolm G. P. Page and David M. Livermore -- 12. Kinetics of [beta]-lactamases and penicillin-binding proteins / Moreno Galleni and Jean-Marie Frere -- 13. The pharmaceutical industry and inhibitors of bacterial enzymes : implications for drug development / David M. Shlaes, Lefa Alksne and Steven J. Projan -- 14. [beta]-lactamase inhibitory proteins / Zhen Zhang and Timothy Palzkill -- 15. Active drug efflux in bacteria / Jurg Dreier -- 16. Overview of dissemination mechanisms of genes coding for resistance to antibiotics / Marcelo E. Tolmasky -- 17. Conjugative transposons / Louis B. Rice -- 18. The dissemination of antibiotic resistance by bacterial conjugation / Virginia L. Waters -- 19. Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics / Juan C. Alonso, Dolors Balsa, Izhack Cherny, Susanne K. Christensen, Manuel Espinosa, Djordje Francuski, Ehud Gazit, Kenn Gerdes, Ed Hitchin, M. Teresa Martin, Concepcion Nieto, Karin Overweg, Teresa Pellicer, Wolfram Saenger, Heinz Welfle, Karin Welfle and Jerry Wells -- 20. Integrons and superintegrons / Robert A. Bonomo, Andrea M. Hujer and Kristine M. Hujer -- 21. The biological cost of antibiotic resistance / Dan I. Andersson, Sophie Maisnier Patin, Annika I. Nilsson and Elisabeth Kugelberg.

ISBN

• 9781555813031
• 1555813038

LCCN

2007002039

OCLC

• ocm80019936
• 80019936
• SCSB-5337993

Owning Institutions

Columbia University Libraries