Research Catalog

Title

The mitochondrion in the germline and early development / edited by Justin C. St. John.

Publication

San Diego, Calif. : Academic Press, [2007], ©2007.

Items in the Library & Off-site

Holdings

Details

Additional Authors

St. John, Justin C.

Description

xiv, 328 pages, 12 unnumbered pages of plates : illustrations.

Summary

"The Mitochondrion in the Germline and Early Development investigates the transmission, transcription and replication of mitochondrial DNA as it is passed through the oocyte into the embryo, fetus and finally live offspring. It discusses the importance of mitochondria to oocyte and embroy development. It analyses the effects of the transmission of mutant mitochondrial DNA, how it might be segregated and how this would impact on offspring viability." "This book also analyses the patterns of transmission, inheritance and replication of mitochondrial DNA following some of the more invasive assisted reproductive techniques such as cloning and again discusses potential impact on offspring viability. It also addresses whether preimplantation genetic diagnosis could be used to predict whether the mutant load in an early embryo would be predictive of the resultant offspring inheriting a mitochondrial disease."--BOOK JACKET.

Series Statement

Current topics in developmental biology ; v. 77

Uniform Title

Current topics in developmental biology ; v. 77.

Subjects

• Gametes
• Human reproductive technology
• Mitochondrial pathology
• Mitochondrial Diseases > genetics
• Mitochondrial DNA
• Germ cells
• Embryology, Human

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. The role of the mitochondrion in sperm function : is there a place for oxidative phosphorylation or is this a purely glycolytic process? / Eduardo Ruiz-Pesini, Carmen Diez-Sanchez, Manuel Jose Lopez Perez and Jose Antonio Enriquez -- 2. The role of mitochondrial function in the oocyte and embryo / Remi Dumollard, Michael Duchen and John Carroll -- 3. Mitochondrial DNA in the oocyte and the developing embryo / Pascale May-Panloup -- 4. Mitochondrial DNA and the mammlian oocyte / Eric A. Shoubridge and Timothy Wai -- 5. Mitochondrial disease - its impact, etiology, and pathology / R. McFarland, R. W. Taylor and D. M. Turnbull -- 6. Cybrid models of mtDNA disease and transmission, from cells to mice / Ian A. Trounce and Carl A. Pinkert -- 7. The use of micromanipulation methods as a tool to prevention of transmission of mutated mitochondrial DNA / Helena Fulka and Josef Fulka, Jr. -- 8. Difficulties and possible solutions in the genetic management of mtDNA disease in the preimplantation embryo / J. Poulton, P. Oakeshott and S. Kennedy -- 9. Impact of assisted reproductive technologies : a mitochondrial perspective of cytoplasmic transplantation / A. J. Harvey, T. C. Gibson, T. M. Quebedeaux and C. A. Brenner -- 10. Nuclear transfer : preservation of a nuclear genome at the expense of its associated mtDNA genome(s) / Emma J. Bowles, Keith H. S. Campbell and Justin C. St. John.

ISBN

• 9780123736628 (alk. paper)
• 0123736625 (alk. paper)

OCLC

• ocm81948688
• 81948688
• SCSB-5357235

Owning Institutions

Columbia University Libraries