Research Catalog

Title

Apoptosis and senescence in cancer / edited by David A. Gerwitz, Shawn E. Holt, Steven Grant.

Publication

Totowa, N.J. : Humana ; Oxford : Blackwell [distributor], 2006.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Gewirtz, David A.
• Holt, Shawn E.
• Grant, Steven.

Description

xvii, 599 pages : illustrations; 27 cm.

Series Statement

Cancer drug discovery and development

Uniform Title

Cancer drug discovery and development.

Subject

• Cancer cells > Regulation
• Cancer > Chemotherapy
• Cancer > Radiotherapy
• Apoptosis
• Granulosa Cell Tumor
• Drug Therapy
• Radiotherapy

Bibliography (note)

• Includes bibliographical references and index.

Contents

Pt. I. Apoptosis and Alternative Modes of Cell Death -- 1. The Intrinsic Pathway of Apoptosis / Scott H. Kaufmann -- 2. The Extrinsic Pathway of Apoptosis / M. Stacey Ricci and Wafik S. El-Deiry -- 3. Evaluating the Importance of Apoptosis and Other Determinants of Cell Death and Survival / Bradly G. Wouters and Roland K. Chiu -- 4. Mitotic Catastrophe / Fiorenza Ianzini and Michael A. Mackey -- 5. Autophagy and Autophagic Cell Death / Mojgan Djavaheri-Mergny, Joelle Botti and Patrice Codogno -- 6. Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis / David J. McConkey and Victor Bondar -- Pt. II. Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis -- 7. Structure and Function of the Telomere / Jay E. Johnson and Dominique Broccoli -- 8. Overview of Senescence / Ruben D. Ramirez -- 9. Contributions of Telomerase to Tumorigenesis / Richard Possemato and William C. Hahn -- 10. The Role of Telomeres in Genomic Instability / John P. Murnane -- Pt. III. DNA Damage Response, Signaling Pathways, and Tumorigenesis -- 11. Overview of the DNA Damage Checkpoint: ATM and ATR / Aude Dupre and Jean Gautier -- 12. Interactions Between Myc- and Cyclin-Dependent Kinase Inhibitors in Cancer / Kirsteen H. Maclean and John L. Cleveland -- 13. Interplay Between [gamma]H2AX and 53BP1 Pathways in DNA Double-Strand Break Repair Response / Fatouros Chronis and Emmy P. Rogakou -- 14. DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy / Lawrence F. Povirk -- Pt. IV. Resistance and Sensitization -- 15. Resistance/Signaling Pathways / Paul Dent, David T. Curiel and Paul B. Fisher -- 16. Ceramide and Multidrug Resistance / Myles C. Cabot -- 17. Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling / Debra L. Smith, Laura K. Nolden, Gordon B. Mills and Yiling Lu -- 18. The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy / Gregory W. Allen and Paul M. Harari -- Pt. V. Established Cancer Therapies -- 19. Antimetabolites / Janet A. Houghton -- 20. Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes / Olivier Sordet, Yves Pommier and Eric Solary -- 21. Perturbations of Cellular Functions by Topoisomerase II Inhibitors: All Roads Lead to Cell Death? / Annette K. Larsen and Andrzej Skladanowski -- 22. The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs / Jan M. Woynarowski and Barbara A. Woynarowska -- 23. Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents / Laura E. Klein and Susan Band Horwitz -- 24. Tyrosine Kinase Inhibitors / Michael Deininger -- Pt. VI. Recent and Developing Cancer Therapies -- 25. Monoclonal Antibodies in Lymphomas / Richard R. Furman, John P. Leonard, Julian Decter and Morton Coleman -- 26. Role of Apoptosis in Anti-Angiogenic Cancer Therapies / Jennifer A. Doll, Jennifer E. Hobbs and Gerald A. Soff -- 27. Photodynamic Therapy-Induced Apoptosis / Nancy L. Oleinick, Rachel L. Morris and Anna-Liisa Nieminen -- 28. Modulation of TRAIL Signaling for Cancer Therapy / Simone Fulda and Klaus-Michael Debatin.

ISBN

• 1588295273 (hbk.)
• 9781588295279 (hbk.)

OCLC

• 501533951
• ocn501533951
• SCSB-5387401

Owning Institutions

Columbia University Libraries