Research Catalog

Title

Computational systems bioinformatics : methods and biomedical applications / Xiaobo Zhou, Stephen T.C. Wong.

Author

Zhou, Xiaobo.

Publication

New Jersey : World Scientific, [2008], ©2008.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Wong, Stephen T. C.

Description

x, 387 pages : illustrations (some color); 24 cm

Summary

"This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research."--BOOK JACKET.

Subject

• Computational biology
• DNA microarrays
• Bioinformatics
• Computational Biology > methods
• Microarray Analysis > methods
• Oligonucleotide Array Sequence Analysis > methods
• Statistics as Topic > methods

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Introduction -- 2. Mathematical, Statistical, and Data Mining Principles -- 3. Missing Value Estimation Using KNN and Bayesian Methods -- 4. Normalization, Scaling, and Discretization -- 5. Cross-platform Comparison -- 6. Discovering Differential Biomarkers -- 7. Gene Selection and Classification -- 8. Gene Clustering -- 9. Gene Prediction -- 10. Reverse Engineering: Gene Regulatory Network Construction and Its Behavior -- 11. Motif Detection and Transcription Factor Binding Site (TFBS) Identification -- 12. Integrated Microarray and Gene Sequence Analysis -- 13. Protein Structure Informatics -- 14. Biomarker Discovery from Proteomics -- 15. Bioimaging Informatics -- 16. Conclusions.

ISBN

• 9789812707048 (hardcover)
• 9812707042 (hardcover)

LCCN

2007037128

OCLC

• ocn171258229
• 171258229
• SCSB-5398394

Owning Institutions

Columbia University Libraries