Research Catalog

Title

Pneumococcal vaccines : the impact of conjugate vaccine / edited by George R. Siber, Keith P. Klugman, P. Helena Mäkelä.

Publication

Washington, DC : ASM Press, [2008], ©2008.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Siber, George R.
• Klugman, Keith P.
• Mäkelä, P. Helena.

Description

xix, 449 pages : illustrations; 29 cm

Summary

"Acute respiratory infections due to pneumococci are the leading vaccine-preventable cause of death. The first pneumococcal conjugate vaccine was licensed 7 years ago in the United States and is now in general use worldwide. While the vaccine's dramatic impact on the target population was anticipated, the magnitude of herd immunity provided to unimmunized individuals was not. This benefit has enormously enhanced the public health impact of the vaccine."--BOOK JACKET.

Subjects

• Pneumonia, Pneumococcal > epidemiology
• Pneumococcal Vaccines > therapeutic use
• Meta-Analysis as Topic
• Pneumococcal Vaccines > immunology
• Pneumococcal vaccine
• Pneumonia, Pneumococcal > prevention & control

Bibliography (note)

• Includes bibliographical references and index.

Contents

Dedication: Robert Austrian / Jeffrey N. Weiser -- I. History -- 1. The History of Pneumococcal Disease / Barry M. Gray and Daniel M. Musher -- 2. History of Pneumococcal Immunization / P. Helena Makela and Jay C. Butler -- II. Biological Basis -- 3. Genetics, Biosynthesis, and Chemistry of Pneumococcal Capsular Polysaccharides / Janet Yother, Stephen D. Bentley and John P. Hennessey, Jr. -- 4. Animal Models of Invasive Pneumococcal Disease / David E. Briles, Susan K. Hollingshead and Ingileif Jonsdottir -- 5. Animal Models of Pneumococcal Colonization / Richard Malley and Jeffrey N. Weiser -- 6. The Immunobiology of Polysaccharide and Conjugate Vaccines / David Goldblatt, Tracy Assari and Clifford Snapper -- 7. Interactions of Streptococcus pneumoniae with Complement Proteins / Margaret K. Hostetter -- III. Clinical Disease and Epidemiology -- 8. Epidemiology, Diagnosis, and Treatment of Serious Pneumococcal Infections in Children / Shabir A. Madhi and Stephen I. Pelton -- 9. Pneumococcal Pneumonia in Adults: Epidemiology, Clinical Features, Diagnosis, and Therapy / Jeffrey B. Rubins, David R. Boulware and Edward N. Janoff -- 10. Pneumococcal Serotype Epidemiology / William P. Hausdorff, Angela B. Brueggemann, Jill G. Hackell and J. Anthony G. Scott -- IV. Manufacturing and Product Release Issues -- 11. Conjugation Chemistry / Andrew Lees, Velupillai Puvanesarajah and Carl E. Frasch -- 12. Pneumococcal Vaccines: Manufacture and Quality Control for Product Release / Milan S. Blake -- 13. Licensing of Pneumococcal Conjugate Vaccines for Children and Adults: Regulatory Perspective from the European Medicines Agency and the U.S. Food and Drug Administration / Marion F. Gruber, Douglas Pratt and Manfred Haase -- V. Immunogenicity -- 14. Quantitation of Anti-Pneumococcal Capsular Antibody in Ligand-Binding Assays / Dace V. Madore, Sally A. Quataert and Merja Vakevainen -- 15. Functional Assays for Pneumococcal Antibody / Moon H. Nahm and Sandra Romero-Steiner -- 16. Immunogenicity and Reactogenicity of Pneumococcal Conjugate Vaccines in Infants and Children / Helena Kayhty, Stephen Lockhart and Lode Schuerman -- 17. Immunogenicity and Safety in Adults / Lisa A. Jackson and George R. Siber -- 18. Immunogenicity in High-Risk and Immunocompromised Children and Adults / Neil French, Sharon Nachman and Stephen I. Pelton -- VI. Efficacy and Safety -- 19. Nasopharyngeal Carriage / Katherine L. O'brien, Ron Dagan and P. Helena Makela -- 20. Acute Otitis Media and Its Sequelae / Terhi Kilpi and Lode Schuerman -- 21. Meta-Analysis of the Efficacy of Conjugate Vaccines against Invasive Pneumococcal Disease / Keith P. Klugman, Felicity Cutts, Richard A. Adegbola, Steven Black, Shabir A. Madhi, Katherine L. O'brien, Mathuram Santosham, Henry Shinefield and Jonathan A. C. Sterne -- 22. Efficacy and Safety of Conjugate Pneumococcal Vaccine in the Prevention of Pneumonia / Shabir A. Madhi and Keith P. Klugman -- 23. Establishing Immune Correlates of Protection / Robert C. Koihberger, Jukka Jokinen and George R. Siber -- VII. Public Health Impact -- 24. Direct and Indirect Effectiveness and Safety of Pneumococcal Conjugate Vaccine in Practice / Cynthia G. Whitney and Matthew R. Moore -- 25. Impact of Conjugate Pneumococcal Vaccine on Antibiotic Resistance / Ron Dagan and Keith P. Klugman -- 26. Pharmacoeconomics of Pneumococcal Conjugate Vaccines / Anushua Sinha and G. Thomas Ray -- 27. Opportunities and Challenges for Pneumococcal Conjugate Vaccines in Low- and Middle-Income Countries / Orin S. Levine and Brian Greenwood -- VIII. Where Next -- 28. Protein Vaccines / James C. Paton and John W. Boslego -- Conclusions / George R. Siber, Keith P. Klugman and P. Helena Makela.

ISBN

• 9781555814083
• 1555814085

LCCN

2007047397

OCLC

• ocn181862805
• 181862805
• SCSB-5401294

Owning Institutions

Columbia University Libraries