Research Catalog

Title

Drug-induced mitochondrial dysfunction / edited by James A. Dykens, Yvonne Will.

Publication

Hoboken, N.J. : John Wiley & Sons, [2008], ©2008.

Supplementary Content

Publisher description

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Dykens, James Alan, 1951-
• Will, Yvonne.

Description

xvii, 616 pages, 12 unnumbered pages of plates : illustrations (some color); 25 cm

Subjects

• Mitochondria > physiology
• Mitochondria > drug effects
• Mitochondrial Diseases > chemically induced
• Drugs > Toxicology
• Mitochondrial pathology

Bibliography (note)

• Includes bibliographical references and index.

Contents

Sect. 1. Basic Concepts -- 1. Basic Mitochondrial Physiology in Cell Viability and Death / Lech Wojtczak and Krzysztof Zablocki -- 2. Basic Molecular Biology of Mitochondrial Replication / Immo E. Scheffler -- 3. Drug-Associated Mitochondrial Toxicity / Rhea Mehta, Katie Chan, Owen Lee, Shahrzad Tafazoli and Peter J. O'Brien -- 4. Pharmacogenomics of Mitochondrial Drug Toxicity / Neil Howell and Corinna Howell -- Sect. 2. Organ Drug Toxicity - Mitochondrial Etiology -- 5. Features and Mechanisms of Drug-Induced Liver Injury / Dominique Pessayre, Alain Berson and Bernard Fromenty -- 6. Cardiovascular Toxicity of Mitochondrial Origin / Paulo J. Oliveira, Vilma A. Sardao and Kendall B. Wallace -- 7. Skeletal Muscle and Mitochondrial Toxicity / Timothy E. Johnson -- 8. Manifestations of Drug Toxicity on Mitochondria in the Nervous system / Ian J. Reynolds -- 9. Lipoatrophy and Other Manifestations of Antiretorviral Therapeutics / Ulrich A. Walker -- 10. Nephrotoxicity / Alberto Ortiz, Alberto Tejedor and Carlos Caramelo -- 11. Drug Effects in Patients with Mitochondrial Diseases / Eric A. Schon, Michio Hirano and Salvatore DiMauro -- Sect. 3. Assessment of Mitochondrial Function in Vitro and in Vivo -- 12. Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function / Erich Gnaiger -- 13. Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function / James Hynes, Tomas C. O'Riordan and Dmitri B. Papkovsky -- 14. Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons / David Ferrick, Min Wu, Amy Swift and Andy Neilson -- 15. Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo / Mark A. Birch-Machin -- 16. OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels / Sashi Nadanaciva -- 17. Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition / Anna-Liisa Nieminen, Venkat K. Ramshesh and John J. Lemasters -- 18. Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum / Patrick J. Halvey, Jason M. Hansen, Lawrence H. Lash and Dean P. Jones -- 19. Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening / Edward E. McKee -- 20. Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis / Michel P. de Baar and Anthony de Ronde -- 21. Clinical Assessment of Mitochondrial Function via [[superscript 13]C]Methionine Exhalation / Laura Milazzo -- 22. Assessment of Mitochondrial Dysfunction by Microscopy / Ingrid Pruimboom-Brees, Germaine Boucher, Amy Jakowski and Jeanne Wolfgang -- 23. Development of Animal Models of Drug-Induced Mitochondrial Toxicity / Urs A. Boelsterli and Yie Hou Lee -- 24. Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy / Robert W. Wiseman and J. A. L. Jeneson -- 25. Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations / Michael P. Murphy.

ISBN

• 9780470111314 (cloth)
• 0470111313 (cloth)

LCCN

2008002720

OCLC

• ocn191127566
• 191127566
• SCSB-5434316

Owning Institutions

Columbia University Libraries