Research Catalog
Nuclear receptors in drug metabolism
- Title
- Nuclear receptors in drug metabolism / edited by Wen Xie.
- Publication
- Hoboken, NJ : John Wiley & Sons, [2009], ©2009.
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1 Item
| Status | Format | Access | Call Number | Item Location |
|---|---|---|---|---|
| Text | Request in advance | RM301.55 .N83 2009 | Off-site |
Holdings
Details
- Additional Authors
- Xie, Wen, 1967-
- Description
- xxii, 330 pages, 8 unnumbered pages of plates : illustrations (some color); 25 cm
- Summary
- "Integrating the findings from several disciplines, Nuclear Receptors in Drug Metabolism enables readers to more accurately predict drug metabolism and drug-drug interactions as well as physiological outcomes. It offers a comprehensive review of the role of nuclear hormone receptors as transcriptional regulators of drug-metabolizing enzymes and transporters, helping readers understand what's known, what's in development, and what's on the horizon. In addition to drug metabolism and drug development, the book also emphasizes clinical drug use, therapeutic potentials, and pharmacogenetics."--BOOK JACKET.
- Subject
- Bibliography (note)
- Includes bibliographical references and index.
- Contents
- 1. Drug Metabolism: Significance and Challenges / Chandra Prakash and Alfin D. N. Vaz -- 2. Establishing Orphan Nuclear Receptors PXR and CAR as Xenobiotic Receptors / Tao Li, Junichiro Sonoda and Ronald M. Evans -- 3. Nuclear Receptor-Mediated Regulation of Phase II Conjugating Enzymes / Olivier Barbier -- 4. Nuclear Receptor-Mediated Regulation of Drug Transporters / Oliver Burk -- 5. Structure and Function of PXR and CAR / X. Edward Zhou and H. Eric Xu -- 6. Xenobiotic Receptor Cofactors and Coregulators / John Y. L. Chiang -- 7. Animal Models of Xenobiotic Nuclear Receptors and Their Utility in Drug Development / Haibiao Gong and Wen Xie -- 8. Nuclear Receptors and Drug-Drug Interactions with Prescription and Herbal Medicines / Rommel G. Tirona and Richard B. Kim -- 9. Genetic Variants of Xenobiotic Receptors and Their Implications in Drug Metabolism and Pharmacogenetics / Jatinder Lamba and Erin G. Schuetz -- 10. Beyond PXR and CAR, Regulation of Xenobiotic Metabolism by Other Nuclear Receptors / Martin Wagner, Gernot Zollner and Michael Trauner -- 11. Emerging Role of Retinoid-Related Orphan Receptor (ROR) and Its Cross Talk with LXR (Liver X Receptor) in the Regulation of Drug-Metabolizing Enzymes / Taira Wada and Wen Xie.
- ISBN
- 9780470086797 (cloth)
- 0470086793 (cloth)
- LCCN
- 2008029786
- OCLC
- ocn230180300
- 230180300
- SCSB-5441757
- Owning Institutions
- Columbia University Libraries