Research Catalog

Title

siRNA and miRNA gene silencing : from bench to bedside / edited by Mouldy Sioud.

Publication

New York, N.Y. : Humana ; [London] : [Springer, distributor], [2009], ©2009.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Sioud, Mouldy.

Description

xiv, 472 pages : illustrations; 27 cm.

Series Statement

• Methods in molecular biology ; 487
• Springer protocols

Uniform Title

• Methods in molecular biology (Clifton, N.J.) ; v. 487.
• Springer protocols (Series)

Subjects

• RNA, Small Interfering
• RNA, Small Interfering > therapeutic use
• Gene silencing
• Small interfering RNA
• MicroRNAs > therapeutic use
• Gene Silencing

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Methods for Selecting Effective siRNA Sequences by Using Statistical and Clustering Techniques / Shigeru Takasaki -- 2. Deciphering the Code of Innate Immunity Recognition of siRNAs / Mouldy Sioud -- 3. Targeted Delivery of Antisense Oligonucleotides and siRNAs into Mammalian Cells / Mouldy Sioud -- 4. Local and Systemic Delivery of siRNAs for Oligonucleotide Therapy / Fumitaka Takeshita, Naomi Hokaiwado, Kimi Honma, Agnieszka Banas and Takahiro Ochiya -- 5. Imaging of siRNA Delivery and Silencing / Anna Moore and Zdravka Medarova -- 6. Recent Advances in Magnetofection and Its Potential to Deliver siRNAs in Vitro / Olga Mykhaylyk, Olivier Zelphati, Edelburga Hammerschmid, Martina Anton, Joseph Rosenecker and Christian Plank -- 7. In Vitro and In Vivo Gene Silencing by TransKingdom RNAi (tkRNAi) / Shuanglin Xiang, Andrew C. Keates, Johannes Fruehauf, Youxin Yang, Hongnian Guo, Thu Nguyen and Chiang J. Li -- 8. Bacterial Delivery of siRNAs: A New Approach to Solid Tumor Therapy / De-Qi Xu, Ling Zhang, Dennis J. Kopecko, Lifang Gao, Yueting Shao, Baofeng Guo and Lijing Zhao -- 9. The Therapeutic Potential of LNA-Modified siRNAs: Reduction of Off-Target Effects by Chemical Modification of the siRNA Sequence / Kees Fluiter, Olaf R. F. Mook and Frank Baas -- 10. pSM155 and pSM30 Vectors for miRNA and shRNA Expression / Junzhu Wu, Akua N. Bonsra and Guangwei Du -- 11. Targeting Oncogenes with siRNAs / Olaf Heidenreich -- 12. Targeting Stromal-Cancer Cell Interactions with siRNAs / Seyedhossein Aharinejad, Mouldy Sioud, Trevor Lucas and Dietmar Abraham -- 13. Therapeutic Potential of siRNA-Mediated Targeting of Urokinase Plasminogen Activator, Its Receptor, and Matrix Metalloproteinases / Christopher S. Gondi and Jasti S. Rao -- 14. Silencing of HIF-1[alpha] by RNA Interference in Human Glioma Cells In Vitro and In Vivo / David L. Gillespie, Jeannette R. Flynn, Brian T. Ragel, Maria Arce-Larreta, David A. Kelly, Sheryl R. Tripp and Randy L. Jensen -- 15. RNA Interference-Mediated Validation of Genes Involved in Telomere Maintenance and Evasion of Apoptosis as Cancer Therapeutic Targets / Marco Folini, Marzia Pennati and Nadia Zaffaroni -- 16. Treating Respiratory Viral Diseases with Chemically Modified, Second Generation Intranasal siRNAs / Sailen Barik -- 17. Progress in the Therapeutic Applications of siRNAs Against HIV-1 / Miguel Angel Martinez -- 18. Protein Components of the microRNA Pathway and Human Diseases / Marjorie P. Perron and Patrick Provost -- 19. Intron-Mediated RNA Interference and microRNA Biogenesis / Shao-Yao Ying and Shi-Lung Lin -- 20. Emergence of a Complex Relationship Between HIV-1 and the microRNA Pathway / Dominique L. Ouellet, Isabelle Plante, Corinne Barat, Michel J. Tremblay and Patrick Provost -- 21. Synthetic microRNA Targeting Glioma-Associated Antigen-1 Protein / Naotake Tsuda, Takahi Mine, Constantin G. Ioannides and David Z. Chang -- 22. Therapeutic Targeting of Gene Expression by siRNAs Directed Against BCR-ABL Transcripts in a Patient with Imatinib-Resistant Chronic Myeloid Leukemia / Michael Koldehoff and Ahmet H. Elmaagacli.

ISBN

• 9781603275460 (hbk.)
• 1603275460 (hbk.)
• 1603275479 (ebk. )
• 9781603275477 (ebk. )

LCCN

2008939423

OCLC

• ocn233934523
• 233934523
• SCSB-5445428

Owning Institutions

Columbia University Libraries