Research Catalog

Title

The kinetochore : from molecular discoveries to cancer therapy / Peter De Wulf, William C. Earnshaw, editors.

Publication

New York ; London : Springer, 2008.

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Holdings

Details

Additional Authors

• De Wulf, Peter.
• Earnshaw, William C.

Description

xiii, 509 pages : illustrations (some color); 25 cm

Summary

"Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs."--BOOK JACKET.

Subject

• Chromosomes
• Cell organelles
• Neoplasms, Second Primary

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Centromeres and Kinetochores: An Historical Perspective / Kerry S. Bloom -- 2. The Basics of Chromosome Segregation / Mitsuhiro Yanagida -- 3. The Centromere / Beth A. Sullivan -- 4. Neocentromeres / Owen J. Marshall and K. H. Andy Choo -- 5. Human Artificial Centromeres: De novo Assembly of Functional Centromeres on Human Artificial Chromosomes / Hiroshi Masumoto, Teruaki Okada and Yasuhide Okamoto -- 6. Kinetochore Composition, Formation, and Organization / Tatsuo Fukagawa and Peter De Wulf -- 7. Evolution of Centromeres and Kinetochores: A Two-Part Fugue / Paul B. Talbert, Joshua J. Bayes and Steven Henikoff -- 8. Mitotic Spindle Assembly Mechanisms / Rebecca Heald and Claire E. Walczak -- 9. Kinetochore-Microtubule Interactions / Lesley Clayton and Tomoyuki U. Tanaka -- 10. Post-Translational Modifications that Regulate Kinetochore Activity / Chitra V. Kotwaliwale and Sue Biggins -- 11. The Role of the Kinetochore in Spindle Checkpoint Signaling / P. Todd Stukenberg and Daniel J. Burke -- 12. Kinetochore Regulation of Anaphase and Cytokinesis / Scott Thomas and Kenneth B. Kaplan -- 13. Roles of Centromeres and Kinetochores in Meiosis / Adele L. Marston -- 14. The Kinetochore-Cancer Connection / Takeshi Tomonaga -- 15. The Kinetochore as Target for Cancer Drug Development / Song-Tao Liu and Tim J. Yen.

ISBN

• 9780387690735 (hbk.)
• 0387690735 (hbk.)

OCLC

• 298595281
• ocn298595281
• SCSB-5447369

Owning Institutions

Columbia University Libraries