Research Catalog

Title

Fragment-based drug discovery : a practical approach / editors, Edward R. Zartler, Michael J. Shapiro.

Publication

Chichester, U.K. : John Wiley & Sons, 2008.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Zartler, Edward.
• Shapiro, Michael (Michael J.)

Description

ix, 285 pages : illustrations; 25 cm

Subjects

• Magnetic Resonance Spectroscopy > methods
• Drugs > Design
• Drug development
• Drug Design
• Ligands
• Ligands (Biochemistry)

Bibliography (note)

• Includes bibliographical references and index.

Contents

Introduction to fragment-based drug discovery / Mike Cherry and Tim Mitchell -- Designing a fragment process to fit your needs / Edward R. Zartler and Michael J. Shapiro -- Assembling a fragment library / Mark Brewer ... [et al.] -- Practical aspects of using NMR in fragment-based screening / Johan Schultz -- Application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses / William J. Metzler ... [et al.] -- Target-immobilized NMR screening : validation and extension to membrane proteins / Virginie Früh, Robert J. Heetebrij, and Gregg Siegal -- In situ fragment-based medicinal chemistry : screening by mass spectrometry / Sally-Ann Poulsen and Gary H. Kruppa -- Computational approaches to fragment and substructure discovery and evaluation / Eelke van der Horst and Adriaan P. IJzerman -- Virtual fragment scanning : current trends, applications and web-based tools / Bradley Feuston ... [et al.] -- Capture methods for fragment-based lead discovery / Stig K. Hansen and Daniel A. Erlanson -- Identification of high affinity [beta]-secretase inhibitors using fragment-based lead generation / Jeffrey S. Albert and Philip D. Edwards.

ISBN

• 9780470058138 (cloth)
• 0470058137 (cloth)

LCCN

2008027930

OCLC

• ocn233544904
• 233544904
• SCSB-5449344

Owning Institutions

Columbia University Libraries