Research Catalog

Title

Process scale purification of antibodies / edited by Uwe Gottschalk.

Publication

Hoboken, N.J. : John Wiley & Sons, [2009], ©2009.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Gottschalk, Uwe.

Description

xxvi, 430 pages : illustrations; 25 cm

Summary

"Biopharmaceutical companies are under extreme pressure to develop robust and economical large-scale processes while consistently meeting regulatory standards for safety and purity. Traditional column chromatography dominates today's purification trains, and many of the productivity gains rely on upscaling such devices. This comes with a cost penalty, however, and further increases in upstream productivity make it a challenge to keep downstream processing manageable. Advances in purification technology are urgently needed to meet the requirements of the marketplace without sacrificing product quality." "Process Scale Purification of Antibodies offers scientists, researchers, and engineers an essential resource that focuses on current best practice in the manufacturing of antibody drugs, addresses problems in antibody purification, and offers suggestions to overcome current challenges and limitations. Written by experts in the field, the book examines old and new separation methods and includes an analysis of innovative trends that can help meet the economic pressures and escalating demand for antibody drugs."--BOOK JACKET.

Subject

• Monoclonal antibodies > Purification
• Biochemical engineering
• Antibodies, Monoclonal > isolation & purification
• Antibodies, Monoclonal > therapeutic use
• Chromatography > methods
• Technology, Pharmaceutical > methods

Note

• Errata slip inserted.

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Downstream Processing of Monoclonal Antibodies: Current Practices and Future Opportunities / Brian Kelley, Greg Blank and Ann Lee -- 2. The Development of Antibody Purification Technologies / John Curling -- 3. Harvest and Recovery of Monoclonal Antibodies: Cell Removal and Clarification / Abhinav A. Shukla and Jagannadha Rao Kandula -- 4. Protein A-Based Affinity Chromatography / Suresli Vrmnum, Ganesh Vedalltham and Brian Hubbard -- 5. Purification of Human Monoclonal Antibodies: Non-Protein A Strategies / Alahari Arunakumari and Jue Wang -- 6. Purification of Monoclonal Antibodies by Mixed-Mode Chromatography / Pete Gagnon -- 7. Integrated Polishing Steps for Monoclonal Antibody Purification / Sanchayita Ghose, Mi Jin, Jia Liu and John Hickey -- 8. Orthogonal Virus Clearance Applications in Monoclonal Antibody Production / Joe X. Zhou -- 9. Development of A Platform Process for the Purification of Therapeutic Monoclonal Antibodies / Yuling Li, David W. Kahn, Olga Galperina, Erich Blatter, Robert Luo, Yaling Wu and Guihang Zhang -- 10. Advances in Technology and Process Development for Industrial-Scale Monoclonal Antibody Purification / Nuno Fontes and Robert van Reis -- 11. Continuous Chromatography for the Purification of Monoclonal Antibodies / Thomas Muller-Spath and Massimo Morbidelli -- 12. Process Economic Drivers in Industrial Monoclonal Antibody Manufacture / Suzanne S. Farid -- 13. Design and Optimization of Manufacturing / Andrew Sinclair -- 14. Alternatives to Packed-Bed Chromatography for Antibody Extraction and Purification / Jorg Thommes and Uwe Gottschalk -- 15. Process-Scale Precipitation of Impurities in Mammalian Cell Culture Broth / Judy Glynn -- 16. Charged Ultrafiltration and Microfiltration Membranes in Antibody Purification / Mark R. Etzel -- 17. Downstream Processing of Monoclonal Antibody Fragments / Mariangela Spitali -- 18. Purification of Antibodies Other Than IgG: The Case of IgM and IgA / Charlotte Cabanne and Xavier Santarelli -- 19. Purification of Antibodies From Transgenic Plants / Zivko L. Nikolov, Jeffrey T. Regan, Lynn F. Dickey and Susan L. Woodard -- 20. Antibody Purification: Drivers of Change / Narahari Pujar, Duncan Low and Rhona O'Leary.

ISBN

• 9780470209622 (cloth)
• 0470209623 (cloth)

LCCN

• 2008038592
• 40016411896

OCLC

• ocn245507386
• 245507386
• SCSB-5457563

Owning Institutions

Columbia University Libraries