Research Catalog

Title

Structure, function, and modulation of neuronal voltage-gated ion channels / edited by Valentin K. Gribkoff, Leonard K. Kaczmarek.

Author

Gribkoff, Valentin K.

Publication

Hoboken, N.J. : Wiley, [2009], ©2009.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Kaczmarek, Leonard K.

Description

xiv, 475 pages, 12 unnumbered pages of plates : illustrations (some color); 25 cm

Summary

"This contributed work features state-of-the-science reviews of the structure, function, and modulation of neuronal voltage-gated ion channels, with an emphasis on their new and emerging applications to drug discovery and development. The reviews, written by leading experts in the field, are either comprehensive reviews of particular voltage-gated ion channel members or in-depth reviews of topics relevant to multiple voltage-gated ion channel subfamilies." "Collectively, this book's reviews provide students and researchers with many new tools and approaches for their current ion channel and drug discovery research. Moreover, the book points the direction to promising areas of investigation worthy of further study."--BOOK JACKET.

Subjects

• Ion Channels
• Drug development
• Pharmaceutical Preparations
• Ion channels > Effect of drugs on
• Molecular pharmacology

Bibliography (note)

• Includes bibliographical references and index.

Contents

Pt. I. Neuronal Voltage-Gated Ion Channel Functions -- 1. Neuronal L-Type Voltage-Gated Calcium Channels / Alexander Scriabine and David J. Triggle -- 2. Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders / Elizabeth Tringham and Terrance P. Snutch -- 3. Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain / Sulayman D. Dib-Hajj, Bryan C. Hains, Joel A. Black and Stephen G. Waxman -- 4. The Role of Ion Channels in the Etiology and Development of Gliomas / Amy K. Weaver and Harald Sontheimer -- 5. Shaker Family K[subscript v]1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons / Helene Vacher and James S. Trimmer -- 6. Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death / Elizabeth A. Jonas -- 7. Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) / Volentin K. Gribkoff and Leonard K. Kaczmarek -- Pt. II. Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function -- 8. Alternative Splicing of Neuronal Ca[subscript v]2 Calcium Channels / Daine Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis and Jesica Raingo -- 9. Effect of Hypoxia/Ischemia on Voltage-Dependent Channels / Xiang Q. Gu, Hang Yao and Gabriel G. Haddad -- 10. In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior / Smith Reddy, Mohammad Shahidullah and Irwin B. Levitan -- 11. Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons / Mark S. Shapiro and Nikita Gamper -- 12. BK Channels: Regulation of Expression and Physiological Impact / Pallob Kundu, Abderrahmane Alioua, Yogesh Kumar, Rong Lu, Jimmy W. Ou, Enrique Sanchez-Pastor, Min Li, Enrico Stefani and Ligia Toro -- 13. Structural Basis for Auxiliary KChIP Modulation of K[subscript v]4 Channels / KeWei Wang and Jijie Chai -- Pt. III. Drug Discovery Targets and Technology -- 14. Sodium Channel Blockers for the Treatment of Chronic Pain / Mark R. Bowlby and Edward Kaftan -- 15. Neuronal K[subscript v]7 Potassium Channels as Emerging Targets for the Treatment of Pain / Steven I. Dworetzky and Valentin K. Gribkoff -- 16. Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels / John E. Starrett, Jr. -- 17. High-Throughput Screening Technologies in Ion Channel Drug Discovery / Edward B. Stevens, Andrew D. Whyment and J. Mark Treherne.

ISBN

• 9780470429891 (cloth)
• 0470429895 (cloth)
• 9780471930136 (hbk.)
• 047193013X (hbk.)

LCCN

2008046707

OCLC

• ocn268957347
• ocn260206990
• 260206990
• 268957347
• SCSB-5460808

Owning Institutions

Columbia University Libraries