Research Catalog

Title

Genomics and pharmacogenomics in anticancer drug development and clinical response / edited by Federico Innocenti.

Publication

Totowa, NJ : Humana, [2008], ©2008.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Innocenti, Federico.

Description

xiv, 377 pages : illustrations (some color); 27 cm.

Series Statement

Cancer drug discovery and development

Uniform Title

Cancer drug discovery and development.

Subjects

• Pharmacogenetics > methods
• Antineoplastic agents > Development
• Cancer > Genetic aspects
• Drug development
• Antineoplastic Agents
• Cancer > Molecular aspects
• Pharmacogenomics
• Genomics
• Neoplasms > drug therapy
• Neoplasms > genetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Toward the realization of the promise of microarrays in oncology / Natalie Stickle and Neil Winegarden -- 2. Cell-based models to identify genetic variants contributing to anticancer drug response / M. Eileen Dolan and Howard McLeod -- 3. Proteomic analysis in cancer patients / Yasuhiro Kuramitsu and Kazuyuki Nakamura -- 4. MicroRNAs and discovery of new targets / Soken Tsuchiya, Yasushi Okuno and Gozoh Tsujimoto -- 5. Pharmacogenomics of the National Cancer Institute's 60-tumor cell panel / Anders Wallqvist, Ruili Huang and David G. Covell -- 6. Use of single-nucleotide polymorphism array for tumor aberrations in gene copy numbers / Kwong-Kwok Wong -- 7. Concordance between tumor and germline DNA / Sharon Marsh -- 8. Epidermal growth factor receptor mutations and sensitivity to selective kinase inhibitors in human lung cancer / Anurag Singh, Sreenath V. Sharma and Jeffrey Settleman -- 9. BCR-ABL mutations and Imatinib resistance in chronic myeloid leukemia patients / Mark R. Litzow -- 10. Role of thymidylate synthase gene variations in colorectal cancer patients / Georg Lurje and Heinz-Josef Lenz -- 11. Thiopurines in the treatment of childhood acute lymphoblastic leukemia and genetic variants of the thiopurine S-methyltransferase gene / Martin Stanulla, Elke Schaeffeler and Matthias Schwab -- 12. Impact of polymorphisms on the clinical outcomes of monoclonal antibody therapy against hematologic malignancies / Dong Hwan Kim -- 13. DNA repair and mitotic checkpoint genes as potential predictors of chemotherapy response in non-small-cell lung cancer / Rafael Roseli, Miquel Taron, Mariacarmela Santarpia, Fernanda Salazar, Jose Luis Ramirez and Miguel Angel Molina -- 14. Dihydropyrimidine dehydrogenase (Dpyd) gene polymorphism : portrait of a serial killer / Joseph Ciccolini, Cedric Mercier and Gerard Milano -- 15. Impact of UDP-glucuronosyltransferase 1A haplotypes on Irinotecan treatment / Kimie Sai, Hironobu Minami, Yoshiro Saito and Jun-ichi Sawada -- 16. Microarray profiling in breast cancer patients / Yong Qian, Xianglin Shi, Vincent Castranova and Nancy L. Guo -- 17. Role of the folate-pathway and the thymidylate synthase genes in pediatric acute lymphoblastic leukemia treatment response / Lea Cunningham and Richard Aplenc -- 18. Pharmacogenomics in drug development : a pharmaceutical industry perspective / Tal Zaks -- 19. Identification of pharmacogenomic biomarker classifiers in cancer drug development / Richard Simon -- 20. Toxicogenomics application to oncology drug development / Luigi Calzolai and Teresa Lettieri -- 21. Strategies to identify pharmacogenomic biomarkers : candidate gene, pathway-based, and genome-wide approaches / Xifeng Wu, Jian Gu and Margaret R. Spitz.

ISBN

• 9781588296467 (hbk. : alk. paper)
• 1588296466 (hbk. : alk. paper)
• 9781603270885 (e-ISBN)
• 1603270884 (e-ISBN)

LCCN

2008938265

OCLC

• ocn166358032
• 166358032
• SCSB-5465671

Owning Institutions

Columbia University Libraries