Research Catalog

Title

Foye's principles of medicinal chemistry / edited by Thomas L. Lemke, David A. Williams ; assistant editors, Victoria F. Roche, S. William Zito [and others].

Publication

Philadelphia : Lippincott Williams & Wilkins, [2008], ©2008.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Foye, William O.
• Lemke, Thomas L.
• Williams, David A., 1938-

Description

xiv, 1377 pages, 8 pages of plates : illustrations (some color); 29 cm

Alternative Title

Principles of medicinal chemistry

Subjects

• Chemistry, Pharmaceutical
• Chimie pharmaceutique
• Pharmaceutical chemistry

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Historical Perspective of Medicinal Chemistry / John L. Neumeyer -- Pt. I. Principles of Drug Discovery -- Ch. 1. Discovery from Natural Products / A. Douglas Kinghorn -- Ch. 2. Drug Design and Relationship of Functional Groups to Pharmacologic Activity / James J. Knittel and Robin M. Zavod -- Ch. 3. Molecular Modeling and In Silico Drug Design / Xiang-Qun (Sean) Xie -- Ch. 4. Receptors and Drug Action / Timothy A. Maher and David A. Johnson -- Ch. 5. Drug Discovery Through Enzyme Inhibition / Stephen Kerr -- Ch. 6. Pharmaceutical Biotechnology - From Nucleic Acids to Personalized Medicine / Ronald E. Reid and Robert D. Sindelar -- Ch. 7. Peptide and Protein Drugs / Michael Mokotoff -- Ch. 8. Antisense Therapeutic Agents / Marilyn Speedie -- Ch. 9. Physicochemical and Biopharmaceutical Properties of Drug Substances and Pharmacokinetics / Sunil S. Jambhekar -- Ch. 10. Drug Metabolism / David A. Williams -- Ch. 11. U.S. Drug Regulation: An Overview / Douglas J. Pisano -- Pt. II. Drug Receptors Affecting Neurotransmission and Enzymes as Catalytic Receptors -- Overview of Drug Receptors: A Perspective / David J. Triggle -- Ch. 12. Drugs Affecting Cholinergic Neurotransmission / E. Kim Fifer -- Ch. 13. Adrenergic Receptors and Drugs Affecting Adrenergic Neurotransmission / Robert K. Griffith -- Ch. 14. Serotonin Receptors and Drugs Affecting Serotonergic Neurotransmission / Richard A. Glennon and Malgorzata Dukat-Glennon -- Ch. 15. Amino Acid Neurotransmitters in the Central Nervous System / Timothy J. Maher -- Ch. 16. Inhibitors of Nerve Conduction: Local Anesthetics / Matthias C. Lu -- Ch. 17. Phosphodiesterase Inhibitors / Kevin Dalby -- Pt. III. Pharmacodynamic Agents -- Ch. 18. General Anesthetics / Timothy J. Maher -- Ch. 19. Sedative-Hypnotics / William Soine -- Ch. 20. Antiseizure Agents / Barbara Leduc -- Ch. 21. Antidepressants / David A. Williams -- Ch. 22. Psychotherapeutic Drugs: Antipsychotic and Anxiolytic Agents / Raymond G. Booth -- Ch. 23. Hallucinogens, Stimulants and Related Drugs of Abuse / Richard A. Glennon -- Ch. 24. Opioid Analgesics / David S. Fries -- Ch. 25. Drugs Used to Treat Neuromuscular Disorders: Antiparkinsonian and Spasmolytic Agents / Raymond G. Booth -- Ch. 26. Cardiac Agents: Cardiac Glycosides, Antianginal, and Antiarrhythmic Drugs / Ahmed S. Mehanna -- Ch. 27. Diuretics / Gary O. Rankin -- Ch. 28. Angiotensin-Converting Enzyme Inhibitors, Antagonists and Calcium Blockers / Marc Harrold -- Ch. 29. Central and Peripheral Sympatholytics and Vasodilators / David A. Williams -- Ch. 30. Antihyperlipoproteinemics and Inhibitors of Cholesterol Biosynthesis / Marc Harrold -- Ch. 31. Antithrombotics, Thrombolytics, Coagulants, and Plasma Extenders / Matthias C. Lu and Thomas L. Lemke -- Ch. 32. Insulin and Drugs Used for the Treatment of Diabetes / Robin M. Zavod, John L. Krstenansky and Bruce L. Currie -- Ch. 33. Adrenocorticoids / Duane D. Miller, Robert W. Brueggemeier and James T. Dalton -- Ch. 34. Thyroid Function and Thyroid Drugs / Ali R. Banijamali -- Ch. 35. Calcium Homeostasis / Robin M. Zavod -- Ch. 36. Nonsteroidal Anti-Inflammatory Drugs / Ronald Borne, Mark Levi and Norman Wilson -- Ch. 37. Antihistamines and Related Antiallergic and Antiulcer Agents / Wendel L. Nelson -- Ch. 38. Antibiotics and Antimicrobial Agents / Lester A. Mitscher, Thomas L. Lemke and Elmer J. Gentry -- Ch. 39. Antiparasitic Agents / Thomas L. Lemke -- Ch. 40. Antifungal Agents / Robert K. Griffith -- Ch. 41. Antimycobacterial Agents / Thomas L. Lemke -- Ch. 42. Cancer and Chemotherapy / Victoria F. Roche -- Ch. 43. Antiviral Agents and Protease Inhibitors / Patrick M. Woster -- Pt. IV. Disease State Management -- Ch. 44. Asthma and Chronic Obstructive Pulmonary Disease / S. William Zito -- Ch. 45. Men's Health / Duane D. Miller, Robert W. Brueggemeier and James T. Dalton -- Ch. 46. Women's Health / Robin M. Zavod -- App. A. pKa Values for Some Drugs and Miscellaneous Organic Acids and Bases -- App. B. pH Values for Tissue Fluids.

ISBN

• 9780781768795
• 0781768799

LCCN

• 2007026228
• 99934249545

OCLC

• 145942325
• ocn145942325
• SCSB-5480876

Owning Institutions

Columbia University Libraries