Research Catalog

Title

Fragment-based approaches in drug discovery / edited by Wolfgang Jahnke and Daniel A. Erlanson.

Publication

Weinheim : Wiley-VCH ; [Chichester] : [John Wiley, distributor], [2006], ©2006.

Items in the Library & Off-site

Holdings

Details

Additional Authors

• Jahnke, Wolfgang.
• Erlanson, Daniel A.

Description

xxii, 369 pages : illustrations (some color); 25 cm.

Series Statement

Methods and principles in medicinal chemistry ; 34

Uniform Title

Methods and principles in medicinal chemistry ; v. 34.

Subjects

• Ligands (Biochemistry)
• Drug development
• Drug Design
• Ligands

Bibliography (note)

• Includes bibliographical references and index.

Contents

The concept of fragment-based drug discovery / Daniel A. Erlanson and Wolfgang Jahnke -- Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, and George M. Whitesides -- Entropic consequences of linking ligands / Christopher W. Murray and Marcel L. Verdonk -- Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe and Carla Mattos -- Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea and Jeffrey M. Blaney -- Structural fragments in marketed oral drugs / Michal Vieth and Miles Siegel -- Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz and Martin Karplus -- NMR-guided fragment assembly / Daniel S. Sem -- SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, and Chaohong Sun -- Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L. M. van Montfort, Glyn Williams, and Harren Jhoti -- Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, and Stephen K. Burley -- Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, and Vincent S. Stoll -- Ligand SAR using electrospray ionizing mass spectrometry / Richard H. Griffey and Eric E. Swayze -- Tethering / Daniel A. Erlanson, Marcus D. Ballinger, and James A. Wells -- Click chemistry for drug discovery / Stefanie Röper and Hartmuth C. Kolb -- Dynamic combinatorial diversity in drug discovery / Matthias Hochgürtel and Jean-Marie Lehn.

ISBN

• 3527312919
• 9783527312917

LCCN

99934532822

OCLC

• ocm67873894\
• 67873894
• SCSB-5484474

Owning Institutions

Columbia University Libraries