Research Catalog

Title

Protein misfolding diseases : current and emerging principles and therapies / edited by Marina Ramirez-Alvarado, Jeffery W. Kelly, Christopher M. Dobson.

Items in the Library & Off-site

Details

Additional Authors

• Dobson, C. M. (Christopher M.)
• Kelly, Jeffery W.
• Ramirez-Alvarado, Marina.

Description

xxx, 1045 p., [24] p. of plates : ill. (some col,); 25 cm.

Summary

"Protein misfolding/aggregation diseases are a medical puzzle that has baffled researchers for many years. These diseases are characterized by the presence of protein deposits, or amyloid fibrils, which gather in the intracellular and/or extracellular spaces in a variety of tissues. Unchecked, the process of amyloidogenesis leads to proteotoxicity, cell loss, and eventually organ dysfunction, and causes such well-known and devastating diseases as Alzheimer's, Parkinson's, and Mad Cow." "Employing a diversity of research approaches, including chemical and biophysical, cellular, and animal models, the authors investigate various amyloid diseases and outline progress made in understanding them in this important book. Included are novel strategies to combat a wide variety of degenerative diseases." "Protein Misfolding Diseases uses the latest medical data from expert scientists and protein misfolding clinicians to launch a multi-targeted assault on the process of amyloid fibril formation. Fresh insight into the etiology of these maladies helps researchers gain a thorough understanding of the bases of these diseases and offers guidance in designing therapeutic strategies to build on promising new findings---and bring hope one step closer to reality."--BOOK JACKET.

Series Statement

Wiley series on protein and peptide science

Subjects

• Proteins > Metabolism > Disorders
• Protein Folding
• Plaque, Amyloid
• Amyloidosis > etiology
• Amyloidosis > therapy
• Amyloidosis > diagnosis
• Protein folding

ISBN

• 0471799289 (cloth)
• 9780471799283 (cloth)

LCCN

2009027972

Owning Institutions

Columbia University Libraries