Research Catalog

Title

Stress-inducible cellular responses / edited by U. Feige ... [et al.].

Publication

Basel ; Boston : Birkhäuser Verlag, c1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Feige, U. (Ulrich), Dr.

Description

xii, 492 p. : ill.; 24 cm.

Summary

This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimental approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins.

Series Statement

EXS ; 77

Uniform Title

EXS ; 77.

Subject

• Stress, Physiological
• Heat-Shock Proteins
• Cell Survival
• Stress (Physiology)
• Cytology
• Heat shock proteins
• Homeostasis
• Cell Biology

Bibliography (note)

• Includes bibliographical references and index.

Processing Action (note)

• committed to retain

Contents

Introduction / I. Yahara -- Normal protein folding machinery / D. Hartman and M.-J. Gething -- Roles for hsp70 in protein translocation across membranes of organelles / D.M. Cyr and W. Neupert -- Protein folding and assembly in the endoplasmic reticulum / J. Wei and L.M. Hendershot -- Involvement of molecular chaperones in intracellular protein breakdown / M. Sherman and A.L. Goldberg -- Molecular chaperoning of steroid hormone receptors / W.B. Pratt, U. Gehring and D.O. Toft -- Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum / J.M. Luz and W.J. Lennarz -- Introduction / R.I. Morimoto -- Sensing stress and responding to stress / R. Voellmy.

ISBN

• 3764352051 (Basel : hardcover : acid-free paper)
• 0817652051 (Boston : hardcover : acid-free paper)

LCCN

^^^96022168^

OCLC

• 34824194
• SCSB-14234233

Owning Institutions

Harvard Library