Research Catalog
Clinical trials of genetic therapy with antisense DNA and DNA vectors / edited by Eric Wickstrom.
- Title
- Clinical trials of genetic therapy with antisense DNA and DNA vectors / edited by Eric Wickstrom.
- Publication
- New York : Dekker, c1998.
Items in the Library & Off-site
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1 Item
| Status | Format | Access | Call Number | Item Location |
|---|---|---|---|---|
| Text | Request in advance | QZ 50.3 C643 1998 | Off-site |
Details
- Additional Authors
- Wickstrom, Eric
- Description
- 427 p. : ill.; 24 cm.
- Summary
- Presents illustrative examples of disease in which gene-based interventions are plausible. Includes case studies of current research using both synthetic oligonucleotides and biological vectors. For pharmacologists, biochemists, pathologists, and medical and graduate students.
- Subjects
- Bibliography (note)
- Includes bibliographical references and index.
- Contents
- Foreword: Genetic Therapy in the 21st Century / O. Michael Colvin -- Preface: From Theory to Practice in Thirty Years / Eric Wickstrom -- 1. A Brief History of Genetic Therapy: Gene Therapy, Antisense Technology, and Genomics / James W. Hawkins -- 2. Preclinical Development of Antisense Oligonucleotide Therapeutics for Cancer: Regulatory Aspects / Chang-Ho Ahn and Joseph J. DeGeorge -- 3. Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices / Jose E. Gonzalez, Richard G. Einig and Patricia Puma -- 4. The Regulatory Process and Gene Therapy / Suzanne L. Epstein -- 5. Production of Clinical Lots of Gene Therapy Vectors Using Good Manufacturing Practice: Experience in a University Setting / Alan R. Davis and Colleen Baker -- 6. Gene Therapy Clinical Trials for Adenosine Deaminase Deficiency/Severe Combined Immunodeficiency / Erlinda M. Gordon and W. French Anderson -- 7. Development of an Oligodeoxynucleotide Pharmaceutical for the Treatment of Human Leukemia / Alan M. Gewirtz and Deborah Lee Sokol -- 8. Clinical Trials with Anti-p53 DNA, OL(1)p53, in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome / Patrick L. Iversen -- 9. Human Bcl-2 Antisense Therapy for Lymphomas / Finbarr E. Cotter, Andrew Webb and Paul Clarke -- 10. Retroviral Gene Transfer in Autologous Bone Marrow and Stem Cell Transplantation / Rafat Abonour and Kenneth Cornetta
- 11. Adenoviral Gene Transfer of the Herpes Virus Thymidine Kinase Gene for Treating Gliomas / Jane B. Alavi, Jason G. Smith and Stephen L. Eck -- 12. Distribution and Toxicity of Retroviral Vectors After Intracavitary Delivery in Mouse and Man / Patrice S. Obermiller, Anne M. Pilaro and Carlos L. Arteaga -- 13. Clinical and Immunologic Responses to Gene Transfer of an Allogeneic Major Histocompatibility Complex Antigen / Alison T. Stopeck and Evan M. Hersh -- 14. Defective Tumor Suppressor Gene Replacement and Oncogene Inactivation for the Treatment of Cancer / Jack Roth -- 15. The Molecular Basis of Bladder Cancer and Prospects for Gene Therapy Using Hammerhead Ribozymes / Eric J. Small, Mohammed Kashani-Sabet and David Y. Bouffard -- 16. In Situ Gene Insertion for Immunotherapy Using Vaccinia Virus Vectors / Edmund C. Lattime, Laurence C. Eisenlohr and Michael J. Mastrangelo -- 17. Antisense Oligonucleotide-Based Therapy for HIV-1 Infection from Laboratory to Clinical Trials / Sudhir Agrawal -- 18. Treatment of Retinitis Induced by Cytomegalovirus Using Intravitreal Fomivirsen (Isis 2922) / Stanley T. Crooke -- 19. Synthetic DNA-Based Compounds for the Prevention of Coronary Restenosis: Current Status and Future Challenges / Andrew Zalewski, Yi Shi and John D. Mannion -- 20. Prevention of Restenosis by Gene Targeting / Michael J. Mann, Heiko E. Von der Leyen and Victor J. Dzau.
- ISBN
- 0824700856 (alk. paper)
- LCCN
- ^^^98013317^
- OCLC
- 38439246
- SCSB-14236537
- Owning Institutions
- Harvard Library