Research Catalog

Title

Oral mucosal drug delivery / edited by Michael J. Rathbone.

Publication

New York : M. Dekker, c1996.

Items in the Library & Off-site

Holdings

Details

Additional Authors

Rathbone, Michael J., 1957-

Description

xiii, 440 p. : ill.; 24 cm.

Summary

"Oral Mucosal Drug Delivery reviews the anatomy and physiology of the oral cavity...analyzes the structure and organization of oral mucosal membranes...discusses both in vitro and in vivo methods for assessing the suitability of a drug for delivery...investigates possibilities for enhancing the permeation of a drug through oral mucosal membranes...includes practical advice on how to overcome on-the-job formulation problems...evaluates the impact saliva flow patterns have on oral mucosal drug delivery...covers special topics such as the use of cell culture models in researching the various processes involved in drug permeation...considers chewing gum as an oral mucosal drug delivery system...and more."--BOOK JACKET.

Series Statement

Drugs and the pharmaceutical sciences ; v. 74

Uniform Title

Drugs and the pharmaceutical sciences v. 74.

Subjects

• Drug Delivery Systems
• Cell Membrane Permeability > physiology
• Mouth Mucosa > metabolism
• Administration, Oral
• Oral mucosa
• Oral medication

Bibliography (note)

• Includes bibliographical references and indexes.

Processing Action (note)

• committed to retain

Contents

1. Structure and Function of the Oral Mucosa and Implications for Drug Delivery / Christopher A. Squier and Philip W. Wertz -- 2. Biochemical Basis of the Permeability Barrier in Skin and Oral Mucosa / Philip W. Wertz, A. Janet Hoogstraate and Christopher A. Squier -- 3. Routes of Drug Transport Across Oral Mucosa / Hao Zhang and Joseph R. Robinson -- 4. Oral Mucosal Permeation Enhancement: Possibilities and Limitations / Bruce J. Aungst -- 5. In Vitro Methods for Measuring Permeability of the Oral Mucosa / Hao Zhang and Joseph R. Robinson -- 6. Buccal Epithelial Cell Cultures as a Model to Study Oral Mucosal Drug Transport and Metabolism / Kenneth E. Audus -- 7. In Vivo Techniques for Studying the Oral Mucosal Absorption Characteristics of Drugs in Animals and Humans / Michael J. Rathbone, Robert Purves, Firoz A. Ghazali and Ping C. Ho -- 8. Flow of Saliva and Its Influence on the Movement, Deposition and Removal of Drugs Administered to the Oral Cavity / John A. Weatherell, Colin Robinson and Michael J. Rathbone -- 9. Salivary Mucins: Their Role in Oral Mucosal Barrier Function and Drug Delivery / Leon C. P. M. Schenkels, Tarikere L. Gururaja and Michael J. Levine -- 10. Mucoadhesive Hydrogels for Buccal Delivery / Ian W. Kellaway and Simon J. Warren -- 11. Systemic Oral Mucosal Drug Delivery and Delivery Systems / Michael J. Rathbone, Gilles Ponchel and Firoz A. Ghazali -- 12. Specialized Oral Mucosal Drug Delivery Systems: Patches / Gary DeGrande, Luce Benes, Francoise Horriere, Herve Karsenty, Claire Lacoste, Roy McQuinn, Jian-Hwa Guo and Robert Scherrer -- 13. Specialized Oral Mucosal Drug Delivery Systems: Chewing Gum / Margrethe Romer Rassing -- 14. Intra-periodontal Pocket Drug Delivery Systems / W. Aubrey Soskolone and Michael Freidman -- 15. Intraoral Delivery of Fluoride / Bernadette K. Drummond and John C. Rodda.

ISBN

0824797442 (hardcover : acid-free paper)

LCCN

^^^96014719^//r96

OCLC

• 34516083
• SCSB-14234871

Owning Institutions

Harvard Library