Research Catalog

Title

Prions : the new biology of proteins / Claudio Soto.

Author

Soto, Claudio, Dr.

Publication

Boca Raton : CRC/Taylor & Francis, c2006.

Items in the Library & Off-site

Details

Description

167 p., [8] p. of plates : ill. (some col.); 24 cm.

Summary

"Prions: The New Biology of Proteins provides a well-organized overview of what is presently known about prion-related diseases. This comprehensive work reviews the clinical symptoms, epidemiology, and neuropathology of the disease. It focuses on evidence supporting the idea that TSEs result from an entirely novel disease mechanism, involving transmission by replication of the misfolding of a single protein in the absence of nucleic acids. Following this hypothesis, the book examines the structure, conversion, and mechanism of prion propagation and details its cellular biology. It explores the transmission of the disease, discusses the challenges involved with diagnosis, and considers the various therapeutic avenues that are presently being explored."--Jacket.

Subject

• Prions
• Prion diseases
• Proteins
• Prion Diseases > physiopathology
• Prions > physiology
• Prion Diseases

Bibliography (note)

• Includes bibliographical references and index.

Processing Action (note)

• committed to retain

Contents

Human and animal diseases: clinical symptoms, epidemiology, and neuropathology -- The infectious agent and the prion hypothesis -- The prion protein: structure, conversion, and mechanism of propagation -- Cell biology, genetic and putative function of the normal prion protein -- Prion strains, species barriers, and multiple conformations of the prion protein -- From the mouth to the brain -- Neurodegeneration in prion diseases -- The diagnosis problem and current tests -- Therapeutic approaches -- Cyclic amplification of prion protein misfolding: rationale, applications, and perspectives -- Other diseases of protein misfolding -- Prions: a common phenomenon in biology?

ISBN

• 9780849314421 (hardcover)
• 0849314429 (hardcover)

LCCN

^^2005044888

OCLC

• 62342822
• SCSB-10019617

Owning Institutions

Harvard Library