Research Catalog

Title

An introduction to systems biology : design principles of biological circuits / Uri Alon.

Author

Alon, Uri, 1969-

Publication

Boca Raton, Fla. : Chapman & Hall/CRC, c2007.

Items in the Library & Off-site

Details

Description

xvi, 301 p., [4] p. of plates : ill. (some col.); 26 cm.

Summary

[Publisher-supplied data] This book presents recently discovered design principles that govern the structure and behavior of biological networks such as gene circuits, highlighting simple, recurring circuit elements that make up the network. It provides a quantitative theory for which circuits are found in a given environment and a mathematical framework for understanding and even designing biological circuits. The book requires only basic mathematics and includes a review of the necessary background material. It fills a significant need for a textbook and introduction to the concepts, principles, and mathematical tools that will form the basis of future developments in the field.

Series Statement

Chapman & Hall/CRC mathematical and computational biology series ; 10

Uniform Title

Chapman and Hall/CRC mathematical & computational biology series 10.

Subject

• Computational biology
• Biological systems > Mathematical models
• Computational Biology
• Systems Biology
• Systems biology
• Gene Regulatory Networks
• Systems Biology > methods

Genre/Form

Internet resource.

Bibliography (note)

• Includes bibliographical references (p. 271-293) and index.

Processing Action (note)

• committed to retain

Contents

Ch. 1. Introduction -- Ch. 2. Transcription networks : basic concepts -- Ch. 3. Autoregulation : a network motif -- Ch. 4. The feed-forward loop network motif -- Ch. 5. Temporal programs and the global structure of transcription networks -- Ch. 6. Network motifs in developmental, signal transduction, and neuronal networks -- Ch. 7. Robustness of protein circuits : the example of bacterial chemotaxis -- Ch. 8. Robust patterning in development -- Ch. 9. Kinetic proofreading -- Ch. 10. Optimal gene circuit design -- Ch. 11. Demand rules for gene regulation -- Ch. 12. Epilogue : simplicity in biology.

ISBN

• 1584886420
• 9781584886426

LCCN

^^2005056902

OCLC

• 62325140
• SCSB-9994723

Owning Institutions

Harvard Library