Research Catalog

Title

Cancer evolution / edited by Charles Swanton [and 4 others].

Publication

Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2017]

Items in the Library & Off-site

Holdings

Details

Additional Authors

Swanton, Charles,

Description

viii, 304 pages : illustrations (some color); 26 cm.

Summary

"Cancer occurs because cells develop mutations that confer a growth advantage. Different subpopulations within the tumor can possess different mutations, and new mutations occur as the cancer progresses. This can allow the tumor to develop resistance to chemotherapy and is a major therapeutic challenge. This book examines this quasi-evolutionary process involved and how work in both molecular and computational biology is shedding light on it. Highlights include: Cancer Stem Cells and Clonal Evolution - Relevance of Sub-Clonal Driver Events to Cancer Evolution and Management - Tumour Heterogeneity--The Achilles Heel for Cancer Immunotherapy - Bioinformatics Approaches to Defining Subclonal Evolution in Cancer Medicine"--

Series Statement

Cold Spring Harbor perspectives in medicine

Uniform Title

Cold Spring Harbor perspectives in medicine.

Subject

• Cancer > Research
• Cancer > Treatment
• Cancer
• MEDICAL / Genetics
• MEDICAL / Oncology
• SCIENCE / Life Sciences / Evolution

Bibliography (note)

• Includes bibliographical references and index.

Contents

Machine generated contents note: -- (preliminary) -- 1. Evolution of Premalignant Disease -- Kit Curtius, Nicholas A. Wright, and Trevor A. Graham -- 2. Cancer Stem Cells and Clonal Evolution -- Tariq Enver -- 3. Spatial Heterogeneity in the Tumor Microenvironment -- Yinyin Yuan -- 4. Tumor Microenvironment and Differential Responses to Therapy -- Eishu Hirata and Erik Sahai -- 5. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity -- John D. Martin, Dai Fukumura, Dan G. Duda, Yves Boucher, and Rakesh K. Jain -- 6. Therapy-Induced Cancer Evolution -- Barry Taylor and Joseph Costello -- 7. Co-Evolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia (CLL) -- Noelia Purroy and Catherine J. Wu -- 8. Tumor Heterogeneity-The Achilles Heel for Cancer Immunotherapy -- Sergio Quezada and Karl Peggs -- 9. Cancer Drug Resistance in Light of Clonal Evolution: Novel Trial Designs -- Robert A. Gatenby -- 10. Order Matters: The Order of Somatic Mutations Influences Cancer Evolution -- David G. Kent and Anthony R. Green -- 11. The Role of Aneuploidy in Cancer Evolution -- Laurent Sansregret and Charles Swanton -- 12. Principles of Reconstructing the Subclonal Architecture of Cancers -- Stefan C. Dentro, David C. Wedge, and Peter Van Loo -- 13. The Cellular Origin and Evolution of Breast Cancer -- Mei Zhang, Adrian V. Lee, and Jeffrey M. Rosen -- 14. Phylogenetic Quantification of Intra-Tumour Heterogeneity -- Thomas B.K. Watkins and Roland F. Schwarz -- 15. Simulating Cancer Evolution Through Space and Time -- Alexander Anderson -- 16. Big Bang Models of Tumor Evolution -- Christina Curtis -- 17. Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies -- Mariangela Russo and Alberto Bardelli -- 18. Studies of Clonal Evolution Simulations in Animals Models -- Sohrab Shah -- 19. Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution -- Samuel F. Bakhoum and Dan Avi Landau -- 20. Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks -- Angelo Fortunato, Amy Broddy, Diego Mallo, Athena Aktipis, Carlo C. Maley, and John W. Pepper -- Index.

ISBN

• 9781621821434
• 1621821439

LCCN

2017017511

Owning Institutions

Princeton University Library