Research Catalog

Title

Preventive chemotherapy in human helminthiasis : coordinated use of anthelminthic drugs in control interventions : a manual for health professionals and programme managers.

Publication

Geneva, Swizterland : World Health Organization, c2006.

Items in the Library & Off-site

Details

Additional Authors

• Crompton, D. W. T. (David William Thomasson), 1937-
• World Health Organization. http://id.loc.gov/authorities/names/n79059041

Description

ix, 62 p. : col. ill.; 26 cm. +

Summary

This manual is intended to guide the coordinated implementation of regular, systematic, large-scale interventions that provide anthelminthic drug treatment as a core component of the joint and synergic control of helminthic diseases such as lymphatic filariasis, onchocerciasis, schistosomiasis and soil-transmitted helminthiasis. The manual focuses mainly on antihelminthic treatment, but other drugs used to eliminate other agents can be potentially associated to those mentioned in the manual; as a reference trachoma control through the SAFE strategy, combining drug treatment with hygiene and environmental management, can be associated to helminth control interventions to boost the overall health of affected communities. The greatest challenge is to extend regular anthelminthic drug coverage as a public health intervention to reach all individuals at risk of the morbidity caused by helminthic infections. Preventive chemotherapy should therefore begin early in life, and every opportunity should be taken to reach at-risk populations. This manual advocates much greater coordination among disease control interventions. Because such large numbers of people are affected, and are often difficult to reach, it also stresses the need to make the best use of all existing drug distribution channels to deliver anthelminthic drugs, and aims at encouraging program managers to find other innovative means of reaching those in need in a sustainable manner.--Publisher's description.

Subjects

• Helminthiasis > Chemotherapy
• Helminthiasis > prevention & control
• Helminthiasis > drug therapy
• Anthelmintics > administration & dosage
• Drugs > Dosage
• Helminthiasis > Prevention

Note

• "A first draft of this manual was prepared by the World Health Organization (WHO) in consultation with Professor D.W.T. Crompton, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland. After circulation to a number of experts, the draft was revised in the light of their comments and input. It was further reviewed at the Informal Consultation on Preventive Chemotherapy in Human Helminthiasis, which took place at WHO headquarters in Geneva, Switzerland, on 16-17 March 2006. Subsequently, WHO staff, in close collaboration with Professor D.W.T. Crompton, who chaired the Informal Consultation, undertook further revision of the manual on the basis of comments and suggestions made by participants. The resulting draft was circulated to all concerned before being finalized for publication. "--P. vi.

Bibliography (note)

• Includes bibliographical references.

Additional Formats (note)

• Also available via the World Wide Web as an Arobat .pdf file (1.57 MB, 74 p.); drug dosage caluculators (135 KB, 6 p.).

Contents

1. Meeting the challenge -- -- 2. Situation analysis -- -- 3. Preventive chemotherapy and its role in the control of helminthiasis -- 3.1 Aim and rationale -- 3.2 Ancillary benefits and advantages of preventive chemotherapy -- -- 4. WHO-recommended drugs: alone and in combination -- -- 5. Preventive chemotherapy: best practice -- 5.1 Eligibility and ineligibility for treatment -- 5.2 Safety and adverse reactions -- 5.2.1 Safety of drug combinations for treatment of helminth infections -- 5.2.2 Safety in pregnancy -- 5.3 Drug quality -- 5.4 Programme implementation -- 5.4.1 Drug delivery and incorporation into established and novel programmes -- 5.4.2 Implementation charts--how to intervene -- 5.5 Different age groups and special risk groups in preventive chemotherapy -- 5.5.1 Preschool children (aged 1-5 years) -- 5.5.2 School-age children (aged 6-15 years) and adults (aged >15 years) -- 5.5.3 Adolescent girls, women of reproductive age and pregnant women -- 5.6 Problems caused by concurrent infections -- -- 6. Measuring and monitoring during preventive chemotherapy -- 6.1 Coverage -- 6.2 Evaluation of impact on morbidity and transmission -- 6.3 Threat of drug resistance and monitoring of drug efficacy -- -- Annexes -- I. Occurrence of lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis and loiasis in countries and territories where preventive chemotherapy interventions may need to be implemented -- II. Rapid assessment and decision charts for schistosomiasis and soil-transmitted helminthiasis -- III. Standardized form for recording serious adverse experiences -- IV. Drug supply, recommended dosages and dose poles -- V. Coverage forms -- VI. Disease-specific information

ISBN

• 9789241547109
• 9241547103

Owning Institutions

Princeton University Library