Research Catalog

Title

Medications development : drug discovery, databases, and computer-aided drug design / editors, Rao S. Rapaka, Richard L. Hawks.

Publication

Rockville, MD : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse, 1993.

Items in the Library & Off-site

Details

Additional Authors

• Hawks, Richard L.
• National Institute on Drug Abuse. http://id.loc.gov/authorities/names/n79096744
• Rapaka, Rao S.

Description

vii, 288 p. : ill.; 24 cm.

Series Statement

• NIDA research monograph ; 134
• NIH publication ; no. 93-3638

Alternative Title

Drug discovery, databases, and computer-aided drug design.

Subjects

• Substance-Related Disorders > Congresses
• Computer-aided design
• Drug Utilization > Congresses
• Drugs > Design > Data processing
• Automatic Data Processing > Congresses
• Drug Design > Congresses

Note

• S/N 017-024-01511-3 (GPO)
• "Based on the papers and discussions from a technical review on ... held on November 14-16, 1991"--T.p. verso.
• Shipping list no.: 93-0586-P.

Bibliography (note)

• Includes bibliographical references.

Contents

Strategies for drug discovery / Michael Williams -- Mass ligand-binding screening strategies for identification of leads for new drug discovery / Ronald M. Burch -- Antibody- and peptide structure-based drug design / Manfred E. Wolff -- The use of cloned human receptors for drug design / Paul R. Hartig -- Synthetic peptide combinatorial libraries may be used to determine peptide ligands for opioid receptors / Richard A. Houghten and Colette T. Dooley -- Preparation of large peptide libraries with one peptide per bead and their use for the discovery of peptides that bind to acceptors / Victor J. Hruby ... [et al.] -- Computer design of bioactive compounds based on 3-D properties of ligands / Y.C. Martin -- Toward the design of new inhibitors : a computer modeling approach / Carlos H. Faerman -- Efforts to improve the utilization of protein sequence and structure databases / Nagarajan Pattabiraman and Krishnan Namboodiri -- Use of computer graphics in drug design / G.W.A. Milne and M.C. Nicklaus -- Purification and cloning of opioid receptors / Ling-Yuan Li ... [et al.] -- Computer-assisted design of dopamine transporter ligands / Gilda H. Loew ... [et al.] -- The pharmacophore for opioid activity / Mark Froimowitz -- The molecular basis of opioid potency and selectivity : morphiceptins, dermorphins, deltorphins, and enkephalins / Murray Goodman ... [et al.] -- Molecular determinants of cannabinoid activity : toward the design of cannabinoid analgesics with reduced psychoactive liability / Patricia H. Reggio -- Cocaine receptor : a structure-activity relationship study / F. Ivy Carroll ... [et al.] -- The use of conformational restriction and molecular modeling techniques in the development of receptor-specific opioid peptide agonists and antagonists / Peter W. Schiller ... [et al.] -- Probes for the cannabinoid sites of action / Alexandros Makriyannis -- A model for the structural basis of [delta]₂-opioid receptor selectivity / Henry I. Mosberg and Frank Porreca.

ISBN

• 0160424771 :
• 9780160424779

LCCN

93231212

Owning Institutions

Princeton University Library