Research Catalog

Title

QuaSAR, quantitative structure activity relationships of analgesics, narcotic antagonists, and hallucinogens / editors, Gene Barnett, Milan Trsic, Robert E. Willette.

Author

National Institute on Drug Abuse. Division of Research.

Publication

Washington, DC : United States Government Printing Office, 1978.

Items in the Library & Off-site

Details

Additional Authors

• Barnett, Gene.
• Trsic, Milan.
• Willette, Robert E.
• United States. Department of Health, Education, and Welfare.

Description

ix, 487 pages : illustrations; 24 cm.

Series Statement

• NIDA research monograph ; 22
• DHEW publication ; no. (ADM) 78-729

Uniform Title

• NIDA research monograph ; 22.
• DHEW publication ; no. (ADM) 78-729.

Subject

• Narcotic antagonists > Analysis
• Analgesics > Analysis
• Hallucinogenic drugs > Analysis
• Drugs > Structure-activity relationships
• Analgesics
• Hallucinogenic drugs > Research > United States
• Narcotic antagonists > Research > United States
• Structure-activity relationships (Biochemistry) > Research > United States
• Hallucinogenic drugs
• Narcotic antagonists
• Structure-activity relationships (Biochemistry)
• Analgesics
• Hallucinogens
• Narcotic Antagonists
• Structure-Activity Relationship
• Narcotic antagonists
• Hallucinogenic drugs
• Analgesics > Analysis
• Drugs > Structure-activity relationships
• Hallucinogenic drugs > Analysis
• Narcotic antagonists > Analysis
• Analgetica
• Hallucinogenen
• QSAR
• Farmacokinetica
• Structuur-activiteit-relatie
• Quimica Quantica

Genre/Form

• Congress
• proceedings (reports)
• Conference papers and proceedings
• Conference papers and proceedings.
• Actes de congrès.

Note

• "Contains the proceedings of a technical review meeting held by the National Institute on Drug Abuse during April 20-22, 1978."

Bibliography (note)

• Includes bibliographies.

Contents

• Section I. Pharmacochemical Methods -- Absolute configuration and psychotomimetic activity / George M. Anderson III, Gisela Braun, Ulrich Braun, David E. Nichols, and Alexander Shulgin -- Congeners of DOM: effect of distribution on the evaluation of pharmacologic data / C.F. Barfknecht, J.F. Caputo, M.B. Tobin, D.C. Dyer, R.T. Standridge, H.G. Howell, W.R. Goodwin, R.A. Partyka, J.A. Gylys, R.L. Cavanagh -- Mescaline analogs: substitutions at the 4-position / Ulrich Braun, Gisela Braun, Peyton Jacob III, David E. Nichols, and Alexander T. Shulgin -- Defining the histamine H₂-receptor in brain: the interaction with LSD / Jack Peter Green, Harel Weinstein, and Saul Maayani -- The nature of opioid and LSD receptors: structural activity relationship implications / William R. Martin -- The use of rigid analogues to probe hallucinogen receptors / David E. Nichols, Herschel J.R. Weintraub, William R. Pfister, and George K.W. Yim -- Section II. Hansch Analysis and Other Empirical Methods -- QSAR: a critical appraisal / Sydney Archer -- QSAR of agents involved in serotonin and LSD binding sites / Y.L. Chan, E.J. Lien, and J.C. Shih -- Structure activity studies by means of the SIMCA pattern recognition methodology / J. Dunn and Svante Wold -- Quantitative relationship between antinociceptive and opiate receptor affinity: the importance of lipophilicity / Arthur E. Hacobson -- Quantitative stereo-structure-activity relationships I. opiate receptor binding / Howard Johnson -- Progress with several models for the study of the SAR of hallucinogenic agents / Lemont B. Kier and Richard A. Glennon -- QSAR of narcotic analgetic agents / E.J. Lien, G.L. Tong, D.B. Srulevitch, and C. Dias -- Section III. Molecular Mechanics -- Quantitative structure-activity relationships in the 2,4,5-ring substituted phenylisopropylamines / George M. Anderson III, Neal Castagnoli, Jr., and Peter A. Kollman -- Assessment of quantum mechanical techniques for use in structure activity relationship development, and application to analgesics and other drugs / B. Vernon Cheney, D.J. Duchamp, Ralph E. Christoffersen.
• Section III. Molecular Mechanics (cont.) -- Recent physiochemical and quantum chemical studies on drugs of abuse and relevant biomolecules / Joyce J. Kaufman -- Structure-activity studies of narcotic agonists and antagonists from quantum chemical calculations / Gilda H. Loew, Donald S. Berkowitz, and Stanley K. Burt -- An extended isolated molecule method and its applications to the design of new drugs: general aspects / Alfredo M. Simas, Roy E. Bruns, and Richard E. Brown -- Recognition and activation mechanisms on the LSD/Serotonin receptor: the molecular basis of structure activity relationships / Harel Weinstein, Jack Peter Green, Roman Osman, and W. Daniel Edwards -- Conformational energies and geometries of narcotics, using a potential function method / Mark Froimowitz -- Conformational study of lysergic acid derivatives in relation to their hallucinogenic and antiserotonin activities / Mahadevappa Kumbar -- Section IV. Spectroscopic Methods -- Carbon-13 nuclear magnetic resonance study of the alpha- and beta- isomers of methadol and acetylmethadol hydrochlorides / F. Ivy Carroll, Charles G. Moreland, George A. Brine, and Karl G. Boldt -- Photoelectron spectroscopic studies of hallucinogens: the use of ionization potentials in QSAR / L.N. Domelsmith and K.N. Houk -- An assessment of parameters in QuaSAR studies of narcotic analgesics and antagonists / Robert Katz, Steven Osborne, Florin Ionescu, Peter Andrulis, Jr., Robert Bates, William Beavers, Paul C.C. Chou, Gilda Loew, and Donald Berkowitz -- Conformational studies on phenethylamine hallucinogens the role of alpha alkyl substitution / Alexandros Makriyannis and James Knittel -- Appendix A. QuaSAR program -- Appendix B. List of participants.

LCCN

78600104

OCLC

• ocm05241050
• 5241050
• SCSB-9119340

Owning Institutions

Princeton University Library