Research Catalog

Title

The world of the cell.

Author

Becker, Wayne M.

Publication

San Francisco : Benjamin Cummings, ©2000.

Items in the Library & Off-site

Details

Additional Authors

• Kleinsmith, Lewis J.
• Hardin, Jeff.

Description

xxxii, 878 pages : illustrations (some color); 29 cm

Summary

This book is intended as a comprehensive introduction to cellular and molecular biology for students preparing for careers in biology, medicine and related fields. Its goal is to present essential principles, processes and methodology.

Subject

• Cytology
• Molecular biology
• Cell Biology
• Molecular Biology
• molecular biology
• Molekularbiologie
• Cytologie

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Part I. The world of the cell: an overview of structure and function. [Ch.1] A preview of the cell -- The cell theory: a brief history -- The emergence of modern cell biology -- Box 1A: units of measurement in cell biology -- Box 1B: further insights: biology, "facts" and the scientific method -- [Ch.2] The chemistry of the cell -- The importance of carbon -- The importance of water -- The importance of selectively permeable membranes -- The importance of synthesis by polymerization -- The importance of self-assembly -- Box 2A: further insights: tempus fugit and the fine art of watchmaking -- [Ch.3] The macromolecules of the cell -- Proteins -- Nucleic acids -- Polysaccharides -- Lipids -- Box 3A: historical perspectives: on the trail of the double helix -- [Ch.4] Cells and organelles -- Properties and strategies of cells -- The eukaryotic cell in overview: pictures at an exhibition -- Viruses, viroids, and prions: agents that invade cells -- Box 4A: historical perspectives: discovering organelles: the importance of centrifuges and chance observation.
• [Ch.5] Bioenergetics: the flow of energy in the cell -- The importance of energy -- Bioenergetics -- Understanding AG -- Life and the steady state: reactions that move toward equilibrium without ever getting there -- Box 5A: further insights: jumping beans and free energy -- Box 5B: historical perspectives: energy and entropy: the Greek connection -- [ch.6] Enzymes: the catalysts of life -- Activation energy and the metastable state -- Enzymes as biological catalysts -- Enzyme kinetics -- Enzyme regulation -- RNA molecules as enzymes: ribozymes -- Box 6A: further insights: monkeys and peanuts -- Box 6B: historical perspective: ATCase: experimental support for allosteric regulation -- Part III. Membranes and cell signaling. [Ch.7] Membranes: their structure, function, and chemistry -- The functions of membranes -- Models of membrane structure: an experimental perspective -- Membrane lipids: the "fluid" part of the model -- Membrane proteins: the "mosaic" part of the model -- Box 7A: contemporary techniques: revolutionizing the study of membrane proteins: the impact of molecular biology.
• [Ch. 8] Transport across membranes: overcoming the permeability barrier -- Cells and transport processes -- Simple diffusion: unassisted movement down the gradient -- Facilitated diffusion: protein-mediated down the gradient -- Active transport: protein-mediated movement up the gradient -- Examples of active transport -- The energetics of transport -- On to nerve cells -- Box 8A: further insights: osmosis: the special case of water transport -- Box 8B: clinical applications: membrane transport, cystic fibrosis, and the prospects for gene therapy -- [Ch. 9] Signal transduction mechanisms: I. Electrical signals in nerve cells -- The nervous system -- Understanding membrane potential -- Electrical excitability -- The action potential -- Synaptic transmission -- Integration and processing of nerve signals -- Box 9A: clinical applications: poisoned arrows, snakebites and nerve gases -- [Ch. 10] Signal transduction mechanisms: II. Messengers and receptors -- Chemical signals and cellular receptors -- G protein: linked receptors -- Protein kinase: associated receptors -- Growth factors as messengers -- The endocrine and paracrine hormone systems -- Box 10A: further insights: g proteins and vision -- Box 10B: further insights: cell signals and programmed cell death.
• [Ch. 11] Beyond the cell: extracellular structures, cell adhesion, and cell junctions -- The extracellular matrix of animal cells -- Fibronectins bind cells to the matrix and guide cellular movement -- Cell-cell recognition and adhesion -- Cell junctions -- The plant cell surface -- Box 11A: clinical applications: understanding blood type: a matter of molecular recognition -- [Ch. 12] Intracellular compartments: the endoplasmic reticulum, golgi complex, endosomes, lysosomes, and peroxisomes -- The endoplasmic reticulum -- The golgi complex -- Roles of the ER and golgi complex in protein glycosylation -- Roles of the ER and golgi complex in protein sorting -- Exocytosis and endocytosis: transporting material across the plasma membrane -- Coated vesicles in cellular transport processes -- Lysosomes and cellular digestion -- The plant vacuole: a multifunctional organelle -- Peroxisomes -- Box 12A: contemporary techniques: centrifugation: an indispensable technique of cell biology -- Box 12B: clinical applications: cholesterol, the LDL receptor, and receptor-mediated endocytosis -- Part III. Energy flow in cells.
• [Ch.13] Chemotrophic energy metabolism: glycolysis and fermentation -- Metabolic pathways -- ATP: the universal energy coupler -- Chemotrophic energy metabolism -- Glycolysis and fermentation: ATP generation without the involvement of oxygen -- Alternative substrates for glycolysis -- Gluconeogenesis -- The regulation of glycolysis and gluconeogenesis -- Box 13A: further insights: "what happens to the sugar?" -- [Ch.14] Chemotrophic energy metabolism: aerobic respiration -- Cellular respiration: maximizing ATP yields -- The mitochondrion: where the action takes place -- The tricarboxylic acid cycle: oxidation in the round -- Electron transport: electron flow from coenzymes to oxygen -- The electrochemical proton gradient: key to energy coupling -- ATP synthesis: putting it all together -- Aerobic respiration: summing it all up -- Box 14A: further insights: the glyoxylate cycle, glyoxysomes, and seed germination -- [Ch.15] Phototrophic energy metabolism: photosynthesis -- An overview of photosynthesis -- The chloroplast: a photosynthetic organelle -- Photosynthetic energy transduction -- Photoreduction (NADPH synthesis) in oxygenic phototrophs -- Photophosphorylation (ATP synthesis) in oxygenic phototrophs -- A photosynthetic reaction center from a purple bacterium -- Photosynthetic carbon assimilation: the calvin cycle -- Photosynthetic energy transduction and the calvin cycle -- Carbohydrate synthesis -- Other photosynthetic assimilation pathways -- Rubisco's oxygenase activity decreases photosynthetic efficiency -- Box 15A: further insights: the endosymbiont theory and the evolution of mitochondria and chloroplasts from ancient bacteria -- Part IV. Information flow in cells.
• [Ch. 16] The structural basis of cellular information: DNA chromosomes, and the nucleus -- The chemical nature of the genetic material -- DNA structure -- The organization of DNA in genomes -- DNA packaging -- The nucleus -- Box 16A: further insights: phages: model systems for studying genes -- Box 16B: further insights: a closer look at restriction enzymes -- Box 16C: contemporary techniques: DNA fingerprinting -- [Ch. 17] The cell cycle: DNA replication, mitosis, and cancer -- An overview of the cell cycle -- DNA replication -- DNA damage and repair -- Nuclear and cell division -- Regulation of the cell cycle -- Growth control and cancer -- Box 17A: contemporary techniques: the PCR revolution -- Box 17B: clinical applications: attacking a tumor's blood supply -- [Ch. 18] Sexual reproduction, melosis, and genetic recombination -- Sexual reproduction -- Meiosis -- Genetic variability: segregation and assortment of alleles -- Genetic variability: recombination and crossing over -- Genetic recombination in bacteria and viruses -- Molecular mechanism of homologous recombination -- Recombinant DNA technology and gene cloning -- Genetic engineering -- Box 18A: historical perspectives: supermouse, an early transgenic triumph.
• [Ch. 19] Gene expression: I. The genetic code and transcription -- The directional flow of genetic information -- The genetic code -- Transcription in prokaryotic cells -- Transcription in eukaryotic cells -- RNA processing -- Key aspects of MRNA metabolism -- Box 19A: further insights: reverse transcription, retroviruses, and retrotransposons -- Box 19B: contemporary techniques: the footprinting method for identifying protein-binding sites on DNA -- [Ch. 20] Gene expression: II. Protein synthesis and sorting -- Translation: the cast of characters -- The mechanism of translation -- Nonsense mutations and suppressor TRNA -- Posttranslational processing -- Protein targeting and sorting -- Box 20A: clinical applications: protein-folding diseases -- Box 20B: a mutation primer -- [Ch. 21] The regulation of gene expression -- Gene regulation in prokaryotes -- Comparison of gene regulation in prokaryotes and eukaryotes -- Eukaryotic gene regulation: genomic control -- Eukaryotic gene regulation: transcriptional control -- Eukaryotic gene regulation: posttranscriptional control -- Box 21A: further insights: dolly: a lamb with no father -- Box 21B: contemporary techniques: discriminating among multiple levels of control -- Part V. The cytoskeleton and cell motility.
• [Ch. 22] Cytoskeletal systems -- The major structural elements of the cytoskeleton -- Techniques for studying the cytoskeleton -- Microtubules -- Microfilaments -- Intermediate filaments -- The cytoskeleton and the tensegrity architecture of cells -- Box 22A: clinical applications: intermediate filaments and the diagnosis of tumors -- [Ch. 23] Cellular movement: motility and contractility -- Motile systems -- Intracellular microtubule-based movement: kinesin and dynein -- Microtubule-based motility -- Actin-based cell movement: the myosins -- Filament-based movement in muscle -- Actin-based motility in nonmuscle cells -- Box 23A: clinical applications: cytoskeletal motor proteins and human disease -- Appendix: principles and techniques of microscopy -- Optical principles of microscopy -- The light microscope -- Sample preparation techniques for light microscopy -- The electron microscope -- Sample preparation techniques for electron microscopy -- Other imaging methods -- Key terms for self-testing -- Suggested reading.

ISBN

• 0805344888
• 9780805344882

LCCN

99040939

OCLC

• ocm41977286
• 41977286
• SCSB-926899

Owning Institutions

Princeton University Library