Research Catalog

Title

Phenothiazines and structurally related drugs; [proceedings] Editors: Irene S. Forrest, C. Jelleff Carr [and] Earl Usdin.

Author

International Symposium on Phenothiazines and Structurally Related Drugs (3rd : 1973 : National Institute of Mental Health (U.S.))

Publication

New York, Raven Press [1974]

Items in the Library & Off-site

Details

Additional Authors

• Forrest, Irene S.
• Carr, C. Jelleff (Charles Jelleff), 1910-
• Usdin, Earl

Description

xxii, 818 pages illustrations; 25 cm.

Series Statement

Advances in biochemical psychopharmacology, v. 9

Uniform Title

Advances in biochemical psychopharmacology ; v. 9.

Subject

• Phenothiazine > Congresses
• Chlorpromazine > Congresses
• Thioxanthenes > Congresses
• Antipsychotic drugs
• Phenothiazine
• Antipsychotic Agents
• Phenothiazines
• Antipsychotic drugs
• Chlorpromazine
• Phenothiazine
• Thioxanthenes

Genre/Form

• Congress
• proceedings (reports)
• Conference papers and proceedings
• Conference papers and proceedings.
• Actes de congrès.

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Search for a relationship between phenothiazine drug metabolism and effectiveness / C. Jelleff Carr -- EPR studies on the mechanism of biotransformation of tricyclic neuroleptics and antidepressants / Helmut Fenner -- Charge transfer interactions of chlorpromazine with neural transmitters / F. Gutmann, Lynne C. Smith, and M.A. Slifkin -- Molecular structure of phenothiazine derivatives / J.J.H. McDowell -- Quantum chemical and other theoretical techniques for the understanding of the psychoactive action of the phenothiazines / Joyce J. Kaufman and Ellen Kerman -- Tentative correlations between some spectroscopic and biological properties of phenothiazine and parafluorobutyrophenone derivatives / Francois Leterrier and Corinne Thiery -- Isolation and characterization of phenothiazine-copper complexes / Ping C. Huang and Sabit Gabay.
• Use of mass spectometry for the identification of metabolites of phenothiazines / A.M. Duffield -- Direct, multiple ion detection of chlorpromazine by mass fragmentography / Donald E. Green -- Discussion / Donald J. Jenden -- Session I: discussion / J. Cymerman Craig -- Membrane actions of tranquilizers in relation to neuroleptic-induced parkinsonism and tardive dyskinesia / P. Seeman [and others] -- Red blood cell drug binding as a possible mechanism for tranquilization / Albert A. Manian [and others] -- Binding of phenothiazines and related compounds to tissues and cell constituents / M.H. Bichel -- Tissue accumulation of metabolites during chronic administration of piperazine-substituted phenothiazine drugs / Ursula Breyer and Hans Jorg Gaertner -- Binding behavior of phenothiazines and structurally related compounds to albumin from several species / Sabit Gabay and Ping C. Huang -- Some aspects of the in vitro oxidation of 35S-chlorpromazine / J.W. Gorrod, C.R. Lazarus, and Arnold H. Beckett.
• Imipramine and chlorpromazine in hepatic microsomal systems / J.M. Perel [and others] -- Pharmacokinetics of 14C-dimethothiazine: distribution and excretion following oral Administration in the dog and rat / Owen R.W. Lewellen and Richard Templeton -- Effect of phenothiazine drugs on the stability of rat liver subcellular particles / C.S. Popov -- Session II: discussion / L.H. Piette -- Sex differences in long-term adverse effects of phenothiazines / Heinz E. Lehmann and Thomas A. Ban -- Evolutionary origin of extrapyramidal disorders in drug-treated mental patients, its significance, and the role of neuromelanin / Fred M. Forrest -- Factors predisposing to drug-induced neurologic effects / George E. Crane -- Effects of promazine and chlorpromazine metabolites on the cornea / H. Richard Adams [and others] -- Pigmented hyperkeratosis among schizophrenic patients treated with nicotinic acid / J.R. Wittenborn [and others] -- Side effects of depot fluphenazines / Frank J. Ayds, Jr.
• Session III: discussion / J.R. Wittenborn -- Further studies of chlorpromazine metabolism in schizophrenic men / Patricia Turano, William J. Turner, and Donald Donato -- Quantitation of chlorpromazine and its metabolites in human plasma and urine by direct spectrodensitometry of thin-layer chromatograms / T.-L. Chan, G. Sakalis, and S. Gershon -- Chlorpromazine analysis by gas chromatography with an electron-capture detector / Stephen H. Curry -- Total excretion of 3H-chlropromazine and 3H-prochlorperazine in chronically dosed animals: balance sheet / I.S. Forrest [and others] -- Hig-pressure chromatographic analysis of phenothiazine-related compounds / William C. Landgraf -- Development of antibodies to chlorpromazine / Sydney Spector -- Immunological properties of some phenothiazines / M. Shostak -- Inhibition of the uptake of monoamines by blood platelets by phenothiazines and other drugs / Liisa Ahtee [and others] -- Session IV: discussion / S. Hess -- Pharmacokinetics of chlorpromazine metabolites -- a colossal problem / Pushkar N. Kaul, Michael W. Conway, and Mervin L. Clark.
• Two types of metabolically produced trifluoperazine N-oxides / M.A. Spirtes -- Use of combined gas chromatography-mass spectrometry techniques for the identification of hydroxylated and dihydroxylated metabolites of phenothiazine drugs / J. Cymerman Craig [and others] -- Autoradiography of 35S-chlorpromazine: accumulation and retention in melanin-bearing tissues / Nils Gunnar Lindquist and Sven Ullberg -- Imipramine protein binding and pharmacokinetics in children / B.G. Winsberg [and others] -- Pharmacokinetics of butaperazine in serum / John M. Davis [and others] -- Metabolic and clinical observations on metiapine in humans / George J. Wright, Robert H. Hook, and Barry Blackwell -- Imipramine steady-state studies and plasma binding / Alexander H. Glassman [and others] -- Session V: discussion / Morris A. Spirtes -- Chemical, pharmacological, and metabolic considerations on thiothixene / Albert Weissman -- Electrocardiographic evaluation of thiothixene: a double-blind comparison with thioridazine -- Robert L. Dillenkoffer [and others] -- Double-blind comparison of thiothixene and trifluoperazine in acute schizophrenia (summary only) / Herman C.B. Denber and Danielle Turns.
• Comparisons of phenothiazine and nonphenothiazine neuroleptics according to psychopathology, side effects and compluterized EEG / Turan M. Itil [and others] -- Double-blind comparison of thiothixene and protriptyline in psychotic depression / Ari Kiev -- Thiothixene in childhood psychoses / Jovan Simeon [and others] -- Session VI: discussion / George Simpson -- Phototoxicity and chlorpromazine photochemistry / Frederick W. Grant -- Activation of L-amino acid oxidase by phenothiazines: thermodynamic and physical chemical studies / D.V. Siva [and others] -- Hydroxylation of 7-hydroxychlorpromazine by mushroom tyrosinase / Thomas A. Grover, Lawrence H. Piette, and Albert A. Manian -- Studies on the metal chelation of chlorpromazine and its hydroxylated metabolites / K.S. Rajan [and others] -- Behavioral, biochemical, and pharmacological effects of chronic dosage of phenothiazine tranquilizers in rats / Roger P. Maickel [and others].
• Effects of hydroxylated phenothiazine metabolites on rat brain mitochondria / Sarah A. Tjioe, Albert A. Manian, and John J. O'Neill -- Pharmacological and behavioral effects of mono- and disubstituted chlorpromazine derivatives / Joseph P. Buckley [and others] -- 7,8-dihydroxychlorpromazine: (Na+ + K+)-ATPase inhibition and positive inotropic effect / T. Akera [and others] -- Session VII: discussion / P. Kaul -- Antipsychotic efficacy of clozapine in correlation to changes in catecholamine metabolism in man / M. Ackenheil [and others] -- Effect of phenothiazines on botulinus intoxication / P. Stern and K. Valjevac -- Clnical differences among phenothiazines in schizophrenics / Leo E. Hollister -- Prediction of neuroleptic effects from animal data / O. Vinar and M. Krsiak -- Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol / Samuel C. Kaim -- Clinical effectiveness of piperacetazine injection in schizophrenic patients: a controlled study / A.S. Kulkarni -- Session VIII: discussion / W. Turner -- Effect of phenothiazines on central cholinergic activity / Melvin H. Van Woert, Vimala H. Sethy, and Lalit M. Ambani.
• Induction of increased aryl hydrocarbon hydroxylase activity by phenothiazines / Lee W. Wattenberg -- Interactions of chlorpromazine with monoamines in the hypothalamic thermoregulatory centers / Peter Lomax and E.E. Kirkpatrick -- Action of chlorpromazine on the metabolism of cyclic adenosine 3',5'-monophosphate / Maria Wollemann -- Inhibition by phenothiazines of adenylate cyclase in adrenal and brain tissue / Charles A. Free, Velma S. Paik, and J. Dennis Shada -- Effects of phenothiazines and phenothiazine metabolites on adenyl cyclase and the cyclic AMP response in the rat brain / Gene C. Palmer and Albert A. Manian -- Effects of chlorpromazine on acetylcholine turnover in vivo / Donald J. Jenden -- Session IX: discussion / Sabit Gabay -- Roundtable conference on relevance of new basic data to clinical parameters -- Summary / Frederick Goodwin.

ISBN

• 0911216618
• 9780911216615

LCCN

73088571

OCLC

• ocm00947680
• 947680
• SCSB-1223657

Owning Institutions

Princeton University Library