Research Catalog

Title

Synthetic peptides as antigens.

Author

Symposium on Synthetic Peptides as Antigens (1985 : Ciba Foundation)

Publication

Chichester ; New York : J. Wiley, 1986.

Items in the Library & Off-site

Details

Additional Authors

• Porter, Ruth.
• Whelan, Julie.
• Ciba Foundation.

Description

x, 307 pages : illustrations; 24 cm.

Summary

Synthetic peptides as antigens Ciba Foundation Symposium 119 Chairman: Gordon L. Ada 1986 Vaccination is a major means of combating infectious disease but no effective vaccine is available yet for many parasitic, viral and bacterial infections. A new approach consists of vaccines based on synthetic peptides rather than native parent antigens. The contributors to this symposium discuss the antigenicity and immunogenicity of synthetic peptides and their potential use in vaccines against malaria and other serious diseases. They consider the relationship between protein conformation and antigenicity, including the role of localized mobility and the conformational changes induced when peptides bind with immunoglobulin. A new method of synthesizing peptides able to mimic discontinuous epitopes is described. The symposium opens with a review of the regulation of immune responses in vivo. Carrier molecules such as PPD are being investigated; carrier choice plays a crucial role in the anti-hCG vaccine (based on a synthetic peptide) being tested as a means of birth control, and discussed here. Synthetic peptides are also of use as research tools, as described for the analysis of IgG sites responsible for autoantibody production in rheumatoid arthritis, and the localization of the c-myc oncoprotein in normal and transformed cells and in tumour masses.

Series Statement

Ciba Foundation symposium ; 119

Uniform Title

Ciba Foundation symposium ; 119.

Subject

• Peptides > Physiological effect > Congresses
• Synthetic antigens > Congresses
• Vaccines > Congresses
• Immune response > Regulation > Congresses
• Peptides
• Peptides > Synthesis
• Antigens
• Antigens > immunology
• Peptides > immunology
• Antigens
• Peptides > Synthesis
• Peptides
• Immune response > Regulation
• Peptides > Physiological effect
• Synthetic antigens
• Vaccines
• Antigen
• Chemische Synthese
• Peptidsynthese
• Synthetische Peptide
• Immunreaktion
• Impfstoff
• Kongress
• Peptide

Genre/Form

• Congress
• proceedings (reports)
• Conference papers and proceedings
• Conference papers and proceedings.
• Actes de congrès.
• London (1985)

Note

• Proceedings of the Symposium on Synthetic Peptides as Antigens, held at the Ciba Foundation, London, 4-6 June 1985.

Bibliography (note)

• Includes bibliographies and indexes.

Contents

Regulation of in vivo immune responses : few principles and much ignorance / J.H. Humphrey -- Raising antibodies by coupling peptides to PPD and immunizing BCG-sensitized animals / P.J. Lachmann, L. Strangeways, A. Vyakarnam, G. Evan -- Selection by site-directed antibodies of small regions of peptides which are ordered in water / H. Jane Dyson, Keith J. Cross, John Ostresh, Richard A. Houghten, Ian A. Wilson, Peter E. Wright, Richard A. Lerner -- Influence of local structure on the location of antigenic determinants in tobacco mosaic virus protein / M.H.V. van Regenmortel, D. Altschuh, A. Klug -- The importance of conformation and of equilibria in the interaction of globular proteins and their fragments with antibodies / Michael J. Crumpton -- Three-dimensional analyses of the binding of synthetic chemotactic and opioid peptides in the MCG light chain dimer / Allen B. Edmundson, Kathryn R. Ely -- The delineation of peptides able to mimic assembled epitopes / H. Mario Geysen, Stuart J. Rodda, Tom J. Mason -- Experimental basis for the development of a synthetic vaccine against Plasmodium falciparum malaria sporozoites / Victor Nussenzweig, Ruth Nussenzweig -- Antigenic repeat structures in proteins of Plasmodium falciparum / R.F. Anders, P-T. Shi, D.B. Scanlon, S.J. Leach, R.L. Coppel, G.V. Brown, H-D. Stahl, D.J. Kemp -- Synthetic peptides with antigenic specificity for bacterial toxins / Michael Sela, Ruth Arnon, Chaim O. Jacob -- Use of synthetic peptides as immunogens for developing a vaccine against human chorionic gonadotropin / Vernon C. Stevens -- The use of synthetic peptides in the delineation of immunoglobulin antigenic epitopes and Fc effector functions / D.R. Stanworth, D.S. Burt, G.Z. Hastings -- Characterization of the human c-myc protein using antibodies prepared against synthetic peptides / Gerard I. Evan, David C. Hancock, Trevor Littlewood, C. David Pauza -- Epitope mapping of human recombinant interferon alpha molecules by monoclonal antibodies / S.S. Alkan, D.G. Braun.

ISBN

• 0471998389
• 9780471998389
• 9780471912033
• 0471912034

LCCN

86156804

OCLC

• ocm15549902
• 15549902
• SCSB-1162290

Owning Institutions

Princeton University Library