Research Catalog

Title

Microbial DNA and host immunity / edited by Eyal Raz.

Publication

Totowa, N.J. : Humana Press, ©2002.

Items in the Library & Off-site

Details

Additional Authors

Raz, E. (Eyal), 1952-

Description

xvii, 408 pages : illustrations; 23 cm

Summary

Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).

Subject

• Bacterial antigens
• DNA vaccines
• Microbial genetics
• Immunological adjuvants
• Vaccines
• DNA, Bacterial > immunology
• Adjuvants, Immunologic
• Vaccines
• Antigens, Bacterial
• Genetics, Microbial
• Vaccines, DNA
• Immunological adjuvants
• Bacterial antigens
• DNA vaccines
• Microbial genetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

pt. 1. Introduction -- Immunostimulatory DNA: an overview / Eyal Raz -- Historial perspectives / Saburo Yamamoto -- pt. 2. Receptors and signaling -- Signal transduction pathways activated by CpG-DNA / Hans Häcker -- A novel toll-like receptor that recognizes bacterial DNA / Hiroaki Hemmi -- Activation of innate immunity by microbial nucleic acids / Wen-Ming Chu -- Phosphorothioate backbone modification changes the pattern of responses to CpG / Katryn J. Stacey -- pt. 3. Cell activation -- Activation of NK cell by immunostimulatory oligo-DNA in mouse and human / Saburo Yamamoto -- Regulation of antigen presenting cell function by CpG DNA / David Askew -- Activation of B cells by CpG motifs in bacterial DNA / Ae-Kyung Yi -- IFN-dependent pathways for stimulation of memory CD8+ cells / Jonathan Sprent -- Cross-priming of CD8+ T cells by immunostimulatory sequence DNA / Hearn Jay Cho -- pt. 4. Vaccination strategies -- The Th1 adjuvant effect of immunostimulatory (ISS) DNA seqences / Maripat Corr -- Immunostimulatory DNA prepriming for the induction of Th1 and prevention of Th2 biased immune responses / Hiroko Kobavashi -- Protein-immunostimulatory DNA-conjugate: a novel immunogen / Kenji Takabayashi -- Immunostimulatory DNA sequence-based mucosal vaccines / Anthony A. Horner -- Enhancement of the immunoadjuvant activity of immunostimulatory DNA sequence by liposomal delivery / Eli Kedar -- Immunostimulatory sequences in plasmid vectors / Christina C.N. Wu -- pt. 4. Applications -- infectious disease -- Comparison fo CpG DNA with other adjuvants for vaccination against Hepatitis B / Michael J. McCkuskie -- Immunostimulatory DNA-based immunization: hope for an HIV vaccine? / Sandip K. Datta -- Immunoprotective activity of CpG oligonucleotides / Dennis M. Klinman -- Protective immunity of immunostimulatory sequences against mycobacterial infection / Tomoko Hayashi -- pt. 6. Applications -- allergy -- DNA-based immunotherapeutics for allergic disease / Anthony A. Horner -- Immunostimulatory DNA for allergic asthma / Reid K. Ikeda -- CpG oligodeoxynucleotides in asthma / Kunihiko Kitagaki -- Modulation of allergic conjuctivitis by immunostimulatory DNA sequence oligonucleotides / Andrea Keane-Myers -- pt. 7. Applications -- cancer -- CpG oligodeoxynucleotides and monoclonal antibody therapy of lymphoma / Thomas L. Warren -- pt. 8. Inflammation and autoimmunity -- The antigenicity of bacterial DNA / David S. Pisetsky -- Inflammatogenic properties of immunostimulatory DNA sequences / Andrej Tarkowski -- The role of immunostimulatory DNA sequences in arthritis / Sarah T.A. Roord -- Effects of immunostimulatory DNA oligonucleotides on experimental colitis / Daniel Rachmilewitz -- pt. 9. Safety considerations -- CpG ODN-safety considerations / Daniela Verthelyi.

ISBN

• 1588290220
• 9781588290229

LCCN

2002068938

OCLC

• ocm50002687
• 50002687
• SCSB-14400860

Owning Institutions

Princeton University Library