Research Catalog

Title

Biocatalysts in organic synthesis / Ján Halgaš.

Author

Halgaš, Ján.

Publication

Amsterdam ; New York : Elsevier, 1992.

Items in the Library & Off-site

Details

Description

xiv, 334 pages : illustrations; 24 cm.

Series Statement

Studies in organic chemistry ; 46

Uniform Title

Studies in organic chemistry (Elsevier Science Publishers) ; 46.

Subject

• Organic compounds > Synthesis
• Enzymes
• Enzymes
• enzyme
• Biokatalysator
• Enzymkatalyse
• Organische Synthese
• Composés organiques > Synthèse

Bibliography (note)

• Includes bibliographical references (p. [301]-324) and index.

Contents

1. Enzymes -- Catalysts of Life. 1.1. Classification of enzymes. 1.2. Principles of the kinetics of enzymatic reactions. 1.2.1. Inhibitors, inhibition with substrate and product. 1.3. Effects of organic solvents on enzymes. 1.4. Effects of temperature and pH on the stability and activity of enzymes. 1.5. Units of enzymatic activity -- 2. The Biocatalyst Form. 2.1. Free enzymes. 2.1.1. Characteristics of free enzymes. 2.1.2. Modified enzymes. 2.2. Immobilized enzymes. 2.2.1. Methods of the enzyme immobilization. 2.2.2. Properties of immobilized enzymes. 2.3. Cells of microorganisms. 2.3.1. Transformations by growing cells. 2.3.2. Transformations by preliminarily grown cells. 2.4. Immobilized cells of microorganisms. 2.4.1. Methods of cell immobilization. 2.4.2. Simultaneous immobilization of several biocatalysts. 2.5. Plant and animal cells. 2.6. Non-enzymatic biopreparations -- 3. Biocatalysts and the Problem of Selectivity in Organic Synthesis. 3.1. Specificity of chemical action and substrate specificity of enzymes. 3.2. Differentiation of enantiomers. 3.3. Differentiation of enantiotopic groups. 3.4. Differentiation of enantiotopic sides -- 4. Substitution Reactions Using Biocatalysts. 4.1. Methylations. 4.2. Halogenations. 4.3. Substitution reactions in the side chain of amino acids. 4.4. Substitutions on aromatic systems with the formation of a C=C bond. 4.5. Substitutions at C-1 in saccharides -- 5. Elimination and Addition Reactions. 5.1. Additions to the C=C bond. 5.2. Additions to the C=O bond -- 6. Syntheses and Hydrolyses of Esters. 6.1. Syntheses of esters. 6.2. Chemo- and regioselective hydrolyses of esters. 6.3. Kinetic resolutions of racemic esters, acids and alcohols. 6.3.1. Hydrolysis and transesterification of esters of racemic acids. 6.3.2. Resolution of racemic alcohols through esters. 6.4. Diesters of prochiral dicarboxylic acids. 6.5. Prochiral diols -- 7. Syntheses and Hydrolyses of Amides. 7.1. Syntheses of amides and peptides. 7.2. Hydrolyses of amides and nitriles -- 8. Oxidations. 8.1. Oxidation of alcohols. 8.2. Further oxidation reactions. 8.2.1. The Baeyer-Villiger oxidation. 8.2.2. Hydroxylations. 8.2.3. Dehydrogenations of the CH-CH bond. 8.2.4. Oxidations of amino acids to oxo acids. 8.2.5. Oxidations of nitrogenous heterocyclic compounds. 8.2.6. Oxidations on nitrogen, sulphur or selenium atoms -- 9. Reductions. 9.1. Reductions of aldehydes and acyclic ketones. 9.2. Reductions of cyclic ketones. 9.3. Reductions of di- and tricarbonyl compounds. 9.4. Reductions of oxo acids, oxo esters and oxo amides. 9.5. Reductions of the carbonyl group in organometallic compounds. 9.6. Reductions of the C=C bond. 9.7. Syntheses of [alpha]-amino acids from [alpha]-oxo acids. 9.8. Reductions of the nitro group. 9.9. Miscellaneous reductions.

ISBN

• 0444986987
• 9780444986986
• 8022403938
• 9788022403931

LCCN

92011638

OCLC

• ocm25630208
• 25630208
• SCSB-1968066

Owning Institutions

Princeton University Library