Research Catalog

The Design of drugs to macromolecular targets

Title: The Design of drugs to macromolecular targets / edited by C.R. Beddell.
Publication: Chichester ; New York : Wiley, ©1992.

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Status	Format	Access	Call Number	Item Location
Request for On-site Use Request Scan How do I pick up this item and when will it be ready?	Book/Text	Use in library	RS420 .D46 1992	Off-site

Details

Additional Authors

Beddell, C. R.

Description

xiv, 287 pages : illustrations (some color); 24 cm

Summary

This text, examining the design of drugs to macromolecular targets, covers such topics as receptor fit technology; drug interactions with target enzymes of known structures; computer modelling of drug-DNA intercalative compounds; and perspectives in medicinal chemistry.

Subject

Bibliography (note)

Includes bibliographical references and indexes.

Contents

The Role of macromolecules in drug action / G.R. Marshall -- Ligand fitting methodology / A.S. Gilbert and J.N. Champness -- Compounds designed to bind to haemoglobin / R. Wootton -- Drug interactions with target enzymes of known structure / B. Roth and D.K. Stammers -- Multiple modes of binding of thyroid hormones and other iodothyronines to human plasma transthyretin / P. de la Paz [and others] -- Computer modelling of drug-DNA intercalative interactions / S. Neidle -- Crystallographic investigations of glycolytic enzymes from trypanasoma brucei: potential starting points for the design of new sleeping sickness drugs / W.G.J. Hol and R.K. Wierenga -- Drug discovery and invention: some approaches compared / A.S. Gilbert and R.M. Hyde.

ISBN

0471920800
9780471920809

LCCN

92005078

OCLC

ocm25317367
25317367
SCSB-9142085

Owning Institutions

Princeton University Library