Research Catalog

The Design of drugs to macromolecular targets

Title
The Design of drugs to macromolecular targets / edited by C.R. Beddell.
Publication
Chichester ; New York : Wiley, ©1992.

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StatusFormatAccessCall NumberItem Location
Book/TextUse in library RS420 .D46 1992Off-site

Details

Additional Authors
Beddell, C. R.
Description
xiv, 287 pages : illustrations (some color); 24 cm
Summary
This text, examining the design of drugs to macromolecular targets, covers such topics as receptor fit technology; drug interactions with target enzymes of known structures; computer modelling of drug-DNA intercalative compounds; and perspectives in medicinal chemistry.
Subject
  • Drugs > Design
  • Macromolecules
  • Molecular recognition
  • Drug Design
  • Macromolecular Substances
  • Arzneimitteldesign
  • Arzneimittelentwicklung
  • Arzneistoffträger
  • Biomolekül
  • Makromolekül
  • Molekulare Erkennung
  • Molekülstruktur
  • Wechselwirkung
  • Aufsatzsammlung
  • Arzneimitteldesign
  • Aufsatzsammlung
  • Molekulare Erkennung
  • Arzneimittelentwicklung
  • Wechselwirkung
Bibliography (note)
  • Includes bibliographical references and indexes.
Contents
The Role of macromolecules in drug action / G.R. Marshall -- Ligand fitting methodology / A.S. Gilbert and J.N. Champness -- Compounds designed to bind to haemoglobin / R. Wootton -- Drug interactions with target enzymes of known structure / B. Roth and D.K. Stammers -- Multiple modes of binding of thyroid hormones and other iodothyronines to human plasma transthyretin / P. de la Paz [and others] -- Computer modelling of drug-DNA intercalative interactions / S. Neidle -- Crystallographic investigations of glycolytic enzymes from trypanasoma brucei: potential starting points for the design of new sleeping sickness drugs / W.G.J. Hol and R.K. Wierenga -- Drug discovery and invention: some approaches compared / A.S. Gilbert and R.M. Hyde.
ISBN
  • 0471920800
  • 9780471920809
LCCN
92005078
OCLC
  • ocm25317367
  • 25317367
  • SCSB-9142085
Owning Institutions
Princeton University Library