Research Catalog

Title

Antibiotics : challenges, mechanisms, opportunities / by Christopher Walsh, ChEM-H Institute, Stanford University and Timothy Wencewicz, Department of Chemistry, Washington University in St. Louis.

Author

Walsh, Christopher

Publication

• Washington, DC : ASM Press, [2016]
• ©2016

Items in the Library & Off-site

Details

Additional Authors

Wencewicz, Timothy A.

Description

x, 477 pages : illustrations (some color); 26 cm

Summary

"Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics." -- Publisher's description.

Subject

• Antibiotics
• Drug resistance in microorganisms
• Anti-Bacterial Agents
• Drug Resistance, Bacterial

Bibliography (note)

• Includes bibliographical references (pages 421-454) and index.

Contents

Challenges for antibiotics -- Mechanism: Antibiotic action by bacterial target class -- Mechanisms: Bacterial resistance to antibiotics -- Mechanisms: Antibiotic biosynthesis -- Opportunities.

ISBN

• 9781555819309
• 1555819303
• 9781555819316 (canceled/invalid)

LCCN

2015045498

OCLC

• ocn931476697
• 931476697
• SCSB-9832356

Owning Institutions

Princeton University Library