Research Catalog

Title

Medicinal chemistry of the renin-angiotensin system / edited by Pieter B.M.W.M. Timmermans and Ruth R. Wexler.

Publication

Lausanne ; New York : Elsevier, 1994.

Items in the Library & Off-site

Details

Additional Authors

• Timmermans, P. B. M. W. M.
• Wexler, Ruth R.

Description

xxvi, 412 pages : illustrations.

Series Statement

Pharmacochemistry library ; v. 21

Uniform Title

Pharmacochemistry library ; v. 21.

Subject

• Renin > Physiological effect
• Renin-angiotensin system
• Angiotensin converting enzyme > Inhibitors > Therapeutic use
• Renin > Inhibitors > Therapeutic use
• Angiotensins > Receptors > Antagonists
• Hypertension > Chemotherapy
• Angiotensin Receptor Antagonists
• Angiotensin-Converting Enzyme Inhibitors > therapeutic use
• Hypertension > drug therapy
• Receptors, Angiotensin > chemistry
• Renin > antagonists & inhibitors
• Renin-Angiotensin System > physiology
• Renin-Angiotensin System

Bibliography (note)

• Includes bibliographical references and index.

Contents

• Foreword / P. B. M. W. M. Timmermans and R. R. Wexler -- Ch. 1. Overview of the Renin Angiotensin System: Targets for Intervention / J. H. Laragh -- Ch. 2. The Inhibition of the Renin-Angiotensin System as a Therapeutic Modality / B. Waeber, M. Burnier and H. R. Brunner -- Ch. 3. Angiotensin Converting Enzyme Inhibitors: New Clinical Applications / S. Anderson and R. E. Hershberger -- Ch. 4. Renin and Prorenin: Processing Mechanisms / D. F. Catanzaro and J. E. Sealey -- Ch. 5. Renin Inhibitor Design Through Molecular Modeling / E. A. Lunney and C. Humblet -- Ch. 6. Current Status of Clinical Trials on Renin Inhibitors / P. van Brummelen -- Ch. 7. Angiotensin II Receptor Antagonists: Design, SAR and Development of Losartan / J. R. Pruitt and R. E. Olson -- Ch. 8. Angiotensin II Receptor Antagonists: Molecular Modeling / R. H. Bradbury, B. B. Masek and D. A. Roberts.
• Ch. 9. Nonpeptide Angiotensin II Receptor Antagonists: Design and SAR of Imidazole-5-Acrylic Acids / R. M. Keenan, J. Weinstock, J. C. Hempel, J. M. Samanen, D. T. Hill, N. Aiyar, D. P. Brooks, E. H. Ohlstein and R. M. Edwards -- Ch. 10. Angiotensin II Receptor Antagonists: Novel Heterocycles / S. E. de Laszlo and W. J. Greenlee -- Ch. 11. Angiotensin II Receptor Antagonists: Non-Biphenyl Tetrazoles / D. Middlemiss and B. C. Ross -- Ch. 12. Heterogeneity of Angiotensin Receptor Subtypes / M. de Gasparo, S. Whitebread, S. P. Bottari and N. R. Levens -- Ch. 13. Molecular Biology of Angiotensin Receptors / P. A. Benfield and M. H. Corjay -- Ch. 14. Functional Correlates of Angiotensin Receptor Stimulation / P. C. Wong and A. F. Hajj-ali -- Ch. 15. The Discovery and Design of Specific Angiotensin AT[subscript 2] Receptor Binding Inhibitors / C. J. Blankley and I. Sircar.
• Ch. 16. Losartan Potassium: Current Clinical Status / E. B. Nelson, C. S. Sweet, S. Shahinfar and M. R. Goldberg -- Ch. 17. Improving Hypertension Treatment. Where Should We Put Our Efforts: New Drugs, New Concepts or New Management? / J. Menard.

ISBN

• 9780444820532
• 0444820531

LCCN

95116971

OCLC

• ocm31769851
• 31769851
• SCSB-14400256

Owning Institutions

Princeton University Library