Research Catalog

Title

Molecular aspects of oxidative drug metabolizing enzymes : their significance in environmental toxicology, chemical carcinogenesis, and health / edited by Emel Arinc̜, John B. Schenkman, Ernest Hodgson.

Publication

Berlin ; New York : Springer-Verlag, ©1995.

Items in the Library & Off-site

Details

Additional Authors

• Arinç, Emel.
• Schenkman, John B.
• Hodgson, Ernest, 1932-
• NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes (1993 : Kuşadası, Turkey)

Description

ix, 614 pages : illustrations; 25 cm.

Series Statement

NATO ASI series. Series H, Cell biology ; vol. 90

Uniform Title

NATO ASI series. Series H, Cell biology ; vol. 90.

Subject

• Cytochrome P-450 > Congresses
• Monooxygenases > Congresses
• Drugs > Metabolism > Congresses
• Xenobiotics > Metabolism > Congresses
• Carcinogenesis > Congresses
• Biochemical toxicology > Congresses
• Oxidation-reduction reaction
• Cytochrome P-450 Enzyme System > chemistry
• Cytochrome P-450 Enzyme System > physiology
• Biotransformation > physiology
• Oxidation-Reduction
• Xenobiotics > metabolism
• Oxidation-reduction reaction
• Biochemical toxicology
• Carcinogenesis
• Cytochrome P-450
• Drugs > Metabolism
• Monooxygenases
• Xenobiotics > Metabolism
• Cytochrome P-450 enzyme system > Physiologie > Congrès comme sujet
• Cytochrome P-450 enzyme system > composition chimique > Congrès comme sujet
• Xénobiotique > Métabolisme > Congrès comme sujet
• Cytochroom P450
• Oxygenases
• Xenobiotica
• Toxicologie
• Kankerverwekkende stoffen
• Toxicologia
• Xénobiotiques > Congrès
• Enzymes > Métabolisme > Congrès
• Toxicologie génétique > Congrès
• Cytochrome P450 > Congrès
• Cancérogenèse > Congrès

Genre/Form

• Congress
• proceedings (reports)
• Conference papers and proceedings
• Conference papers and proceedings.
• Actes de congrès.

Note

• "Proceedings of the NATO Advanced Study Institute on Molecular Aspects of Drug Metabolizing Enzymes, held in Kus̜adasi, Aydin-Turkey, June 20-July 2, 1993"--T.p. verso.

Bibliography (note)

• Includes bibliographical references and index.

Contents

Introduction to Cytochrome P450 / J. B. Schenkman and I. Jansson -- General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5 / E. Arinc -- Interaction Between Cytochrome P450 and Reductase / J. B. Schenkman and A. I. Voznesensky -- Molecular Biology of Cytochrome P450: Evolution, Structure and Regulation / Y. Fujii-Kuriyama and O. Gotoh -- The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators / E. F. Johnson, C. N. A. Palmer, M.-H. Hsu and K. J. Griffin -- Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis / T. H. Richardson, M.-H. Hsu and E. F. Johnson -- Diversity and Regulation of Cytochromes P450 in Aquatic Species / J. J. Stegeman -- Cytochrome P450 Expression in Rainbow Trout: An Overview / D. R. Buhler -- Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity / C. S. Yang and J.-Y. Hong -- Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics / R. M. Philpot and L. Overby -- Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function / R. M. Philpot, E. A.-A.-Adjei, K. Nikbakht, V. Burnett and M. P. Lawton -- Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways / E. Hodgson, B. L. Blake, P. E. Levi, R. B. Mailman, M. P. Lawton, R. M. Philpot and M. B. Genter -- Developmental Regulation of Biotransformation of Drugs and Other Xenobiotics / W. Klinger -- Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical / C. S. Yang and T. J. Smith -- Mechanisms of Mutagenicity and Tumour Formation / D. Anderson -- Genotoxicity Assays / D. Anderson -- Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals / F. Oesch, F. Fahndrich, H. R. Glatt, B. Oesch-Bartlomowicz, K.-L. Platt and D. Utesch -- Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites / F. Oesch, H. J. Arens, F. Fahndrich, T. Friedberg, B. Richter, H. Yamazaki and B. Oesch-Bartlomowicz -- The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics / J. Doehmer -- In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo / J. Doehmer -- The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides / E. Hodgson, R. L. Rose, N. H. Adams, N. J. Demaer, M. B. Genter, K. Venkatesh and P. E. Levi -- Metabolism of Xenobiotic Proestrogens and Estrogens by Cytochrome P450 / D. Kupfer -- Metabolism of Antiestrogenic Anti-Cancer Agents by Cytochrome P450 and Flavin-Containing Monooxygenases. Mechanism of Action Involving Metabolites / D. Kupfer -- Therapeutic Agents and Cytochrome P450 / A. Y. H. Lu -- Drug Metabolism, Lipid Peroxidation and Glutathione / W. Klinger -- Health Environment of Altai Territory and Monooxygenase and Conjugating Activities in Placentae of Newborn / S. Kotelevtsev, V. V. Obrazsov, C. N. Novicov and L. I. Stepanova -- Monooxygenase Measurements as Indicators of Pollution in the Field / R. F. Addison -- Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea / S. V. Kotolevtsev and L. I. Stepanova -- Relating Biochemical Responses to "Higher Order" Effects / R. F. Addison.

ISBN

• 3540588566
• 9783540588566

LCCN

94047314

OCLC

• ocm31739648
• 31739648
• SCSB-2057777

Owning Institutions

Princeton University Library